Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question

Margaret H Baron¹, Jeffrey Barminko²

Affiliations

¹ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: margaret.baron@mssm.edu.
² Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

PMID: 26954541
DOI: 10.1016/j.devcel.2016.02.014

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Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question

Margaret H Baron et al. Dev Cell. 2016.

Free article

. 2016 Mar 7;36(5):481-2.

doi: 10.1016/j.devcel.2016.02.014.

Authors

Margaret H Baron¹, Jeffrey Barminko²

Affiliations

¹ Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: margaret.baron@mssm.edu.
² Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

PMID: 26954541
DOI: 10.1016/j.devcel.2016.02.014

Abstract

Differentiating erythroid cells undergo dramatic changes in morphology, with reduction in cell size, chromatin and nuclear condensation, and enucleation. In this issue of Developmental Cell, Zhao et al. (2016) show that these events are associated with the formation of transient, recurring nuclear openings and selective histone release mediated by caspase-3.

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Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening.
Zhao B, Mei Y, Schipma MJ, Roth EW, Bleher R, Rappoport JZ, Wickrema A, Yang J, Ji P. Zhao B, et al. Dev Cell. 2016 Mar 7;36(5):498-510. doi: 10.1016/j.devcel.2016.02.001. Dev Cell. 2016. PMID: 26954545 Free PMC article.

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Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question

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Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question

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