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Comment
. 2016 Mar 7;36(5):485-6.
doi: 10.1016/j.devcel.2016.02.018.

Sticking Around: Short-Range Activity of Wnt Ligands

Michael Boutros  1 , Christof Niehrs  2
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Free article
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Sticking Around: Short-Range Activity of Wnt Ligands

Michael Boutros et al. Dev Cell. .
Free article

Abstract

Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report that Wnt3 acts at a short distance during growth of mouse intestinal organoids, suggesting that Wnt proteins remain membrane-bound to activate signaling at a short range from their source.

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