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. 2016 Mar-Apr;37(2):83-8.
doi: 10.1016/j.amjoto.2015.10.002. Epub 2015 Oct 8.

Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study

Serdar Kaya  1 , Vladimir Tsuprun  2 , Ömer Hızlı  3 , Patricia A Schachern  2 , Michael M Paparella  4 , Sebahattin Cureoglu  5
Affiliations

Cochlear changes in serous labyrinthitis associated with silent otitis media: A human temporal bone study

Serdar Kaya et al. Am J Otolaryngol. 2016 Mar-Apr.

Abstract

Purpose: To determine histopathological findings in the cochlea of human temporal bones with serous labyrinthitis.

Materials and methods: We compared human temporal bones with serous labyrinthitis (20 cases) associated with silent otitis media and without serous labyrinthitis (20 cases) to study location of serous labyrinthitis, the degree of endolymphatic hydrops, number of spiral ganglion cells and hair cells, loss of fibrocytes in the spiral ligament, and areas of the spiral ligament and stria vascularis.

Results: The serous labyrinthitis caused significant loss of outer hair cells in the lower basal (P=0.006), upper basal (P=0.005), and lower middle (P=0.011) cochlear turns, and significant increase in the degree of endolymphatic hydrops than the control group (P=0.036). No significant difference was found in the loss of inner hair cells, in the number of spiral ganglion cells and fibrocytes in the spiral ligament, and in areas of the stria vascularis and spiral ligament (P>0.05).

Conclusions: Serous labyrinthitis resulted in significant loss of outer hair cells and significant increase in the degree of endolymphatic hydrops.

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Figures

Figure 1
Figure 1
Diagram showing mean number of spiral ganglion cells by segment. SL: serous labyrinthitis; n.s. = not significant
Figure 2
Figure 2
Diagram showing mean loss (%) of outer hair cells (OHCs). SL: serous labyrinthitis; * P < 0.05; n.s. = not significant
Figure 3
Figure 3
Photomicrograph showing loss of outer hair cells (OHCs) in the temporal bone from an 18-year-old man with serous labyrinthitis. A. Low-power image of upper basal turn and lower middle turn. Thick arrow = mucopurulent secretion; thin arrow = fibrous structure; arrowhead = fibrocystic structure. B. Enlarged view of box A. Arrows = loss of OHCs. * serous labyrinthitis. C. Enlarged view of box B. Arrows = loss of OHCs. * serous labyrinthitis. Staining with hematoxylin-eosin (H&E).
Figure 3
Figure 3
Photomicrograph showing loss of outer hair cells (OHCs) in the temporal bone from an 18-year-old man with serous labyrinthitis. A. Low-power image of upper basal turn and lower middle turn. Thick arrow = mucopurulent secretion; thin arrow = fibrous structure; arrowhead = fibrocystic structure. B. Enlarged view of box A. Arrows = loss of OHCs. * serous labyrinthitis. C. Enlarged view of box B. Arrows = loss of OHCs. * serous labyrinthitis. Staining with hematoxylin-eosin (H&E).
Figure 3
Figure 3
Photomicrograph showing loss of outer hair cells (OHCs) in the temporal bone from an 18-year-old man with serous labyrinthitis. A. Low-power image of upper basal turn and lower middle turn. Thick arrow = mucopurulent secretion; thin arrow = fibrous structure; arrowhead = fibrocystic structure. B. Enlarged view of box A. Arrows = loss of OHCs. * serous labyrinthitis. C. Enlarged view of box B. Arrows = loss of OHCs. * serous labyrinthitis. Staining with hematoxylin-eosin (H&E).
Figure 4
Figure 4
Photomicrograph showing moderate endolymphatic hydrops in the temporal bone from a 71-years-old man. A. Lower magnification image shows serous labyrinthitis in vestibule. B. Higher magnification of the cochlea. C: cochlea; S: saccule; U: utricle. Arrows = endolymphatic hydrops. * serous labyrinthitis. Staining with hematoxylin-eosin (H&E).
Figure 4
Figure 4
Photomicrograph showing moderate endolymphatic hydrops in the temporal bone from a 71-years-old man. A. Lower magnification image shows serous labyrinthitis in vestibule. B. Higher magnification of the cochlea. C: cochlea; S: saccule; U: utricle. Arrows = endolymphatic hydrops. * serous labyrinthitis. Staining with hematoxylin-eosin (H&E).
Figure 5
Figure 5
Diagram showing mean area (μm2) of the stria vascularis. SL: serous labyrinthitis; n.s. = not significant
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