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. 2016 Feb 24:9:101-4.
doi: 10.2147/JPR.S103238. eCollection 2016.

A touchy subject: an assessment of cutaneous allodynia in a chronic migraine population

Affiliations

A touchy subject: an assessment of cutaneous allodynia in a chronic migraine population

Paul G Mathew et al. J Pain Res. .

Abstract

Background: Cutaneous allodynia (CA) is a common feature of migraine, which has a complex underlying pathophysiology that is not well understood. In addition to pain, photophobia, phonophobia, osmophobia, nausea, and vomiting, CA can contribute to the overall disability caused by migraine. The presence of CA can be established via a validated questionnaire. Validated questionnaires and other tests are rarely performed in clinical practice. As such, current prevalence estimates for CA may be an underestimation.

Methods: Utilizing a validated questionnaire, we assessed the presence of CA in consecutive patients (n=44) presenting with chronic migraine at a tertiary headache center.

Results: CA appears to be quite prevalent, at ~90%, among female patients with chronic migraine.

Conclusion: CA prevalence in chronic migraine may be underestimated in the literature, and larger studies may better demonstrate a more accurate estimate of its prevalence.

Keywords: central sensitization; headache; migraine chronification; validated questionnaire.

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Figures

Figure 1
Figure 1
Breakdown of allodynia scores.

References

    1. Lipton RB, Stewart WF, Simon D. Medical consultation for migraine: results from the American Migraine Study. Headache. 1998;38:87–96. - PubMed
    1. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache. 2001;41:646–657. - PubMed
    1. Zhao H, Eising E, de Vries B, et al. International Headache Genetics Consortium. Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Cephalalgia. 2015 Dec 8; Epub. - PMC - PubMed
    1. Milner P. Note on a possible correspondence between the scotomas of migraine and spreading depression of Leao. Electroencephalogr Clin Neurophysiol. 1958;10:705. - PubMed
    1. Goadsby PH, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28:183–187. - PubMed