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Review
. 2016 Jan-Mar;7(1):9-14.
doi: 10.4103/2229-3485.173780.

Comparative effectiveness research and its utility in In-clinic practice

Amit Dang  1 , Kirandeep Kaur  2
Affiliations
Review

Comparative effectiveness research and its utility in In-clinic practice

Amit Dang et al. Perspect Clin Res. 2016 Jan-Mar.

Abstract

One of the important components of patient-centered healthcare is comparative effectiveness research (CER), which aims at generating evidence from the real-life setting. The primary purpose of CER is to provide comparative information to the healthcare providers, patients, and policy makers about the standard of care available. This involves research on clinical questions unanswered by the explanatory trials during the regulatory approval process. Main methods of CER involve randomized controlled trials and observational methods. The limitations of these two methods have been overcome with the help of new statistical methods. After the evidence generation, it is equally important to communicate the results to all the interested organizations. CER is beginning to have its impact in the clinical practice as its results become part of the clinical practice guidelines. CER will have far-reaching scientific and financial impact. CER will make both the treating physician and the patient equally responsible for the treatment offered.

Keywords: Comparative effectiveness research; observational studies; randomized controlled trials.

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References

    1. Institute of Medicine. Initial National Priorities for Comparative Effectiveness Research. 2009. [Last accessed on 2015 May 07]. Available from: http://www.iom.edu/Reports/2009/ComparativeEffectivenessResearchPrioriti... .
    1. Manchikanti L, Falco FJ, Boswell MV, Hirsch JA. Facts, fallacies, and politics of comparative effectiveness research: Part I. Basic considerations. Pain Physician. 2010;13:E23–54. - PubMed
    1. Tunis SR, Benner J, McClellan M. Comparative effectiveness research: Policy context, methods development and research infrastructure. Stat Med. 2010;29:1963–76. - PubMed
    1. GAO. US Government Accountability Office. Comparative Effectiveness Research. HHS Needs to Strengthen Dissemination and Data-Capacity-Building Efforts. [Last accessed on 2015 Apr 04]. Available from: http://www.gao.gov/products/GAO-15-280 .
    1. Agency for Healthcare Research and Quality. Effective Health Care Program. [Last accessed on 2015 May 07]. Available from: http://effectivehealthcare.ahrq.gov/index.cfm/what-is-comparative-effect...