Tumor-associated macrophages and anti-tumor therapies: complex links

doi:10.1007/s00018-016-2166-5

Review

. 2016 Jul;73(13):2411-24.

doi: 10.1007/s00018-016-2166-5. Epub 2016 Mar 8.

Tumor-associated macrophages and anti-tumor therapies: complex links

Cristina Belgiovine¹, Maurizio D'Incalci², Paola Allavena³, Roberta Frapolli²

Affiliations

¹ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy. cristina.belgiovine@humanitasresearch.it.
² Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156, Milan, Italy.
³ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

PMID: 26956893
PMCID: PMC11108407
DOI: 10.1007/s00018-016-2166-5

Review

Tumor-associated macrophages and anti-tumor therapies: complex links

Cristina Belgiovine et al. Cell Mol Life Sci. 2016 Jul.

. 2016 Jul;73(13):2411-24.

doi: 10.1007/s00018-016-2166-5. Epub 2016 Mar 8.

Authors

Cristina Belgiovine¹, Maurizio D'Incalci², Paola Allavena³, Roberta Frapolli²

Affiliations

¹ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy. cristina.belgiovine@humanitasresearch.it.
² Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via La Masa 19, 20156, Milan, Italy.
³ Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

PMID: 26956893
PMCID: PMC11108407
DOI: 10.1007/s00018-016-2166-5

Abstract

Myeloid cells infiltrating the tumor microenvironment, especially tumor-associated macrophages (TAMs), are essential providers of cancer-related inflammation, a condition known to accelerate tumor progression and limit the response to anti-tumor therapies. As a matter of fact, TAMs may have a dual role while interfering with cancer treatments, as they can either promote or impair their functionality. Here we review the connection between macrophages and anticancer therapies; moreover, we provide an overview of the different strategies to target or re-program TAMs for therapeutic purposes.

Keywords: Anti-tumor therapies; Cancer-related inflammation; Macrophage targeting; Nanoparticles; Tumor-associated macrophages.

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Figures

**Fig. 1**
Different strategies to target macrophages. a Inhibition of macrophages recruitment by suppressing CCL2 or CSF1/CSF1R signaling. b Pharmacological depletion of macrophages through the administration of liposomal encapsulated clodronate or trabectedin. c Reprogramming macrophages from M2 to M1 like phenotype

See this image and copyright information in PMC

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References

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[1] Hume DA. The mononuclear phagocyte system. Curr Opin Immunol. 2006;18(1):49–53. doi: 10.1016/j.coi.2005.11.008. - DOI - PubMed

[2] Hume DA. The mononuclear phagocyte system. Curr Opin Immunol. 2006;18(1):49–53. doi: 10.1016/j.coi.2005.11.008. - DOI - PubMed

[3] Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–455. doi: 10.1038/nature12034. - DOI - PMC - PubMed

[4] Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–455. doi: 10.1038/nature12034. - DOI - PMC - PubMed

[5] Martinez-Pomares L, Reid DM, Brown GD, et al. Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. J Leukoc Biol. 2003;73(5):604–613. doi: 10.1189/jlb.0902450. - DOI - PubMed

[6] Martinez-Pomares L, Reid DM, Brown GD, et al. Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. J Leukoc Biol. 2003;73(5):604–613. doi: 10.1189/jlb.0902450. - DOI - PubMed

[7] Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23(4):344–346. doi: 10.1016/j.immuni.2005.10.001. - DOI - PubMed

[8] Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity. 2005;23(4):344–346. doi: 10.1016/j.immuni.2005.10.001. - DOI - PubMed

[9] Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25(12):677–686. doi: 10.1016/j.it.2004.09.015. - DOI - PubMed

[10] Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25(12):677–686. doi: 10.1016/j.it.2004.09.015. - DOI - PubMed

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Tumor-associated macrophages and anti-tumor therapies: complex links

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Tumor-associated macrophages and anti-tumor therapies: complex links

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