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. 2016 Mar;14(3):255-64.
doi: 10.6004/jnccn.2016.0031.

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 4.2016

David S Ettinger  1 , Douglas E Wood  2 , Wallace Akerley  3 , Lyudmila A Bazhenova  4 , Hossein Borghaei  5 , David Ross Camidge  6 , Richard T Cheney  7 , Lucian R Chirieac  8 , Thomas A D'Amico  9 , Thomas J Dilling  10 , M Chris Dobelbower  11 , Ramaswamy Govindan  12 , Mark Hennon  7 , Leora Horn  13 , Thierry M Jahan  14 , Ritsuko Komaki  15 , Rudy P Lackner  16 , Michael Lanuti  17 , Rogerio Lilenbaum  18 , Jules Lin  19 , Billy W Loo Jr  20 , Renato Martins  12 , Gregory A Otterson  20 , Jyoti D Patel  21 , Katherine M Pisters  15 , Karen Reckamp  22 , Gregory J Riely  23 , Steven E Schild  24 , Theresa A Shapiro  1 , Neelesh Sharma  25 , James Stevenson  25 , Scott J Swanson  8 , Kurt Tauer  26 , Stephen C Yang  1 , Kristina Gregory  27 , Miranda Hughes  27
Affiliations

NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 4.2016

David S Ettinger et al. J Natl Compr Canc Netw. 2016 Mar.

Abstract

These NCCN Guidelines Insights focus on recent updates in the 2016 NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC; Versions 1-4). These NCCN Guidelines Insights will discuss new immunotherapeutic agents, such as nivolumab and pembrolizumab, for patients with metastatic NSCLC. For the 2016 update, the NCCN panel recommends immune checkpoint inhibitors as preferred agents (in the absence of contraindications) for second-line and beyond (subsequent) therapy in patients with metastatic NSCLC (both squamous and nonsquamous histologies). Nivolumab and pembrolizumab are preferred based on improved overall survival rates, higher response rates, longer duration of response, and fewer adverse events when compared with docetaxel therapy.

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