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Review
. 2016 Jan-Mar;8(1):2-17.
doi: 10.4103/0975-7406.171694.

Current status of pyrazole and its biological activities

Mohd Javed Naim  1 , Ozair Alam  1 , Farah Nawaz  1 , Md Jahangir Alam  1 , Perwaiz Alam  2
Affiliations
Review

Current status of pyrazole and its biological activities

Mohd Javed Naim et al. J Pharm Bioallied Sci. 2016 Jan-Mar.

Abstract

Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole. This has been followed by an in depth analysis of the pyrazole with respect to their medical significance. This follow-up may help the medicinal chemists to generate new leads possessing pyrazole nucleus with high efficacy.

Keywords: Anti-microbial; hetrocyclic and biological activity; pyrazole.

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Figures

Figure 1
Figure 1
Different biological activities depicted by pyrazole moiety
Figure 2
Figure 2
Pyrazole containing drugs
Figure 3
Figure 3
Synthesis of 1,3- and 1,3,5-substituted pyrazoles
Figure 4
Figure 4
Synthesis of tri- and tetra-substituted pyrazoles
Figure 5
Figure 5
Synthesis of 3,5-substituted-1H-pyrazole
Figure 6
Figure 6
Synthesis of 3-benzofuran-2-yl-1-p-tolyl-1H-pyrazole derivatives
Figure 7
Figure 7
Synthesis of 1-(4,5-disubstitutedpyrazol-1-yl)-ethanone
Figure 8
Figure 8
Synthesis of 1,3,5-trisubstituted-1H-pyrazole
Figure 9
Figure 9
Synthesis of substituted pyrazole derivatives
Figure 10
Figure 10
Syntheis of novel pyrazole derivatives
Figure 11
Figure 11
Synthesized 22 1,3,4-trisubstituted pyrazole derivatives
Figure 12
Figure 12
Synthesized substituted indole based scaffolds having a pyrazole ring
Figure 13
Figure 13
Synthesis of a novel series of ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates
Figure 14
Figure 14
Synthesis of benzophenones from 1-methyl-5-(2, 4, 6-trimethoxyphenyl)-1H-pyrazole
Figure 15
Figure 15
Synthesized a series of novel 1-acetyl-3-(3,4-dimethoxypheny)-5-(4-(3-(arylureido/arylthioureido/arylsulfonamido) phenyl)-4,5-dihydropyrazole derivatives
Figure 16
Figure 16
Synthesis of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehydes
Figure 17
Figure 17
Synthesis of N-((5-(4-chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methylene)-3,5bis(trifluoromethyl)aniline
Figure 18
Figure 18
Synthesis of 3-phenyl-N-[3-(4-phenylpiperazin-1yl) propyl]-1H-pyrazole-5-carboxamide derivatives
Figure 19
Figure 19
2-[5-(2-chloro-phenyl)-1H-pyrazol-3-yl]-6-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-3,5-dimethoxy-phenol
Figure 20
Figure 20
Synthesis of 4-thiazolyl pyrazolyl derivatives
Figure 21
Figure 21
Synthesis of 1-(2, 4-Chloroacridine-9-yl)-3-(5-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one
Figure 22
Figure 22
Synthesis of 1-(2,4-dimethoxy-phenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-propenone
Figure 23
Figure 23
Synthesis of novel pyrazole derivatives
Figure 24
Figure 24
Bis (3-aryl-4,5-dihydro-1H-pyrazole-thiocarboxamides)
Figure 25
Figure 25
N,NDimethylaminomethylene-4-[3-phenyl-4-(3-substituted-4-oxothiazolidin-2 ylidenehydrazonomethyl)-1H-pyrazolyl] derivatives
Figure 26
Figure 26
1-thiocarbamoyl 3-substituted phenyl-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole derivatives
Figure 27
Figure 27
Substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives
Figure 28
Figure 28
Synthesized 3-(5-Bromo-2-thienyl)-4-[1-phenylthiocarbamoyl-3-(4-methylphenyl)-2-pyrazolin-5-yl]-1-phenyl-1H-pyrazole
Figure 29
Figure 29
(2-aryl-1-cyclopentenyl-1-alkylidene) (arylmethyloxy) amine
Figure 30
Figure 30
Synthesis of pyrazoline analogs
Figure 31
Figure 31
Substituted 4,6-diarylpyrimidin-2-amine (4), 4,6-diaryl-2-(heteroaryl) pyrimidine
Figure 32
Figure 32
Substituted 5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine
Figure 33
Figure 33
4-dihydro-3Hindeno[ 1,2-c]pyrazole-2-carboxamide
Figure 34
Figure 34
Fused pyrazolepyrimidine derivatives
Figure 35
Figure 35
1,5-diaryl pyrazole
Figure 36
Figure 36
Synthesis of 2,4-disubstituted oxazol-5-one
Figure 37
Figure 37
1-acetyl- 3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives
Figure 38
Figure 38
1, 3, 4, 5 tetrasubstituted pyrazole derivatives
Figure 39
Figure 39
4,5-dihydro-1-H-pyrazole
Figure 40
Figure 40
Tetra-substituted pyrazole derivatives
Figure 41
Figure 41
1,5-diarylpyrazoles analogs
Figure 42
Figure 42
3-substituted-N-aryl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide
Figure 43
Figure 43
5amino-1-substiuted pyrazole-3,3,4-tricarbonitriles
Figure 44
Figure 44
1-acetyl-3-(4-hydroxy- and 2,4-dihydroxyphenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole derivatives
Figure 45
Figure 45
4, 5-disubstituted pyrazole derivatives
Figure 46
Figure 46
Substituted pyrazole derivatives
Figure 47
Figure 47
Synthesis of pyrazole derivatives
Figure 48
Figure 48
5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid
Figure 49
Figure 49
Synthesis of imidazo[2,1-b]thiazoles having pyrazole moieties
Figure 50
Figure 50
Synthesis of pyrazole quinolonepyridine hybrids
Figure 51
Figure 51
N-(4-(Pyrazol-4-yl)thiazol-2- yl)-N0-phenylthiourea derivative
Figure 52
Figure 52
S-substituted-1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl) phenyl pyrazole moiety
Figure 53
Figure 53
Trisubstituted pyrazole derivatives
Figure 54
Figure 54
Synthesis of 3-(3,4-dimethylphenyl)-5-(4-methoxy phenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Figure 55
Figure 55
6-{2-[4-(4 methyl piperazin-1-yl)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-2,4-dihydro-indeno [1,2-c] pyrazole
Figure 56
Figure 56
(E)-1-aryl-3-(3-aryl-1- phenyl-1H-pyrazol-4-yl)prop-2-en-1-one(pyrazolicchalcones)
Figure 57
Figure 57
3-aryl-1-(4- tert-butylbenzyl)-1H-pyrazole-5-carbohydrazide hydrazone derivatives
Figure 58
Figure 58
1H pyrazole-4-carboxylic acid ethyl esters
Figure 59
Figure 59
Novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives
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References

    1. Perrin DD. London: Butterworths; 1972. Dissociation Constants of Organic Bases in Aqueous Solution.
    1. Eicher T, Hauptmann S. 2nd ed. New York: Wiley-VCH; 2003. The Chemistry of Heterocycles: Structure, Reactions, Synthesis and Applications.
    1. Katz AM, Pearson CM, Kennedy JM. A clinical trial of indomethacin in rheumatoid arthritis. Clin Pharmacol Ther. 1965;6:25–30. - PubMed
    1. Ilango K, Valentina P. 1st ed. India: Keerthi Publishers; 2007. Textbook of Medicinal Chemistry; pp. 327–33.
    1. Panda N, Jena AK. Fe-catalyzed one-pot synthesis of 1,3-di- and 1,3,5-trisubstituted pyrazoles from hydrazones and vicinal diols. J Org Chem. 2012;77:9401–6. - PubMed