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. 2015 Sep;15(3):728-36.
doi: 10.4314/ahs.v15i3.5.

Anti-HCV antibody among newly diagnosed HIV patients in Ughelli, a suburban area of Delta State Nigeria

Ogbodo Ekene Newton  1 , Otue Akpevwe Oghene  2 , Iheanyi Omezuruike Okonko  2
Affiliations

Anti-HCV antibody among newly diagnosed HIV patients in Ughelli, a suburban area of Delta State Nigeria

Ogbodo Ekene Newton et al. Afr Health Sci. 2015 Sep.

Abstract

Background: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share common routes of infection and as such, co-infection is expected. Co-infection of the two viruses is of great medical importance as it determines the effect of drugs used for treatment at various stages.

Objective: This interplay between HIV and HCV sets the tone for the objective of this study which is to ascertain the seroprevalence of HCV among newly diagnosed HIV patients in Ughelli, a suburban area of Delta State, Nigeria.

Methods: A total of 200 newly diagnosed HIV-positive patients were recruited for this study. Each of the sera was tested for anti-HCV antibody using SWE-life HCV ultra rapid test strip. Appropriate questionnaires were used to ascertain other important information which include social behaviour such as whether the patients were MSM (males), IDU, tattoo and/or have received blood transfusion in the past.

Results: The prevalence of HCV among the study population was determined to be 15.0%. A higher seroprevalence was observed among females (16.5%) than in males (13.0%). A higher seroprevalence was also observed among age groups >26 years (16.0%) than in age-groups 14-25 years (13.0%) and 2-13 years (0.0%). Of the 7 patients with tattoos, 1(14.3%) tested positive for HCV compared to 29(15.0%) with no tattoos. We found no significant correlation with transfusion, intravenous drug use (IDU), men that have sex with men (MSM), tattooing and the seroprevalence of HCV. However, significant correlation existed with age, sex and HCV prevalence.

Conclusion: This study reports a 15.0% seroprevalence of HCV among newly diagnosed HIV patients and that is alarmingly well above several other studies done in the past in Nigeria and other countries of sub-Saharan Africa. Planned preven tion, screening, and treatment are needed to reduce further transmission and morbidity. Future studies involving HCV-RNA assays are needed.

Keywords: HCV; HIV; Hepatitis; co-infection; intravenous drug use.

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Figures

Figure 1
Figure 1
HCV prevalence among newly diagnosed HIV patients prevalence among newly diagnosed HIV patients
Figure 2
Figure 2
HCV prevalence among people living with HIV by gender Significantly associated (p<0.05)
Figure 3
Figure 3
HCV prevalence among people living HIV according age groups Significantly associated (p<0.05)
See this image and copyright information in PMC

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