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. 2015 Sep;15(3):851-60.
doi: 10.4314/ahs.v15i3.20.

Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda

Daniel Mumpe-Mwanja  1 , Suzanne Verver  2 , Adoke Yeka  3 , Alfred Etwom  4 , James Waako  5 , Willy Ssengooba  6 , Joseph Kb Matovu  7 , Rhoda K Wanyenze  8 , Phillipa Musoke  9 , Harriet Mayanja-Kizza  10
Affiliations

Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda

Daniel Mumpe-Mwanja et al. Afr Health Sci. 2015 Sep.

Abstract

Background: Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy.

Objectives: We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda.

Methods: We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression.

Results: The prevalence of latent TB was 16.1%, 95% CI (15.1 - 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 - 1.48); male gender, APR 1.37 (95% CI 1.21 - 1.56); age 17 -18 years, APR 1.46 (95% CI 1.24 - 1.71) and 15-16 years, APR 1.25 (95% CI 1.07 - 1.46) compared to 12-14 years; being out of school, APR 1.31 (95% CI 1.05 - 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 - 2.35).

Conclusion: Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.

Keywords: Adolescents; Latent tuberculosis infection; Risk factors; Tuberculin skin testing; Tuberculosis.

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Figures

Figure 1
Figure 1
Distribution of TST induration diameter among the study participants∞ ∞We excluded 3000 participants with zero TST induration diameters; this graph includes TST readings for 1981 participants.
Figure 2
Figure 2
Distribution of LTBI (positive TST) within the age strata.
See this image and copyright information in PMC

References

    1. WHO, author. Global tuberculosis report 2013. 2013
    1. WHO, author. Global tuberculosis report 2012. 2012
    1. Raviglione MC. The Global Plan to Stop TB, 2006–2015. Int J Tuberc Lung Dis. 2006;10(3):238–239. - PubMed
    1. Rowland R, McShane H. Tuberculosis vaccines in clinical trials. Expert Rev Vaccines. 2011;10(5):645–658. - PMC - PubMed
    1. WHO, author. TB/HIV Clinical Manual. Second ed. Geneva: WHO; 2012.

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