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Review
. 2016 Mar 5;5(3):33.
doi: 10.3390/jcm5030033.

Acute Myeloid Leukemia: A Concise Review

Jennifer N Saultz  1 , Ramiro Garzon  2
Affiliations
Review

Acute Myeloid Leukemia: A Concise Review

Jennifer N Saultz et al. J Clin Med. .

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation testing remain a critical prognostic tool for post induction treatment. Despite rapid advances in the field including new drug targets and increased understanding of the biology, AML treatment remains unchanged for the past three decades with the majority of patients eventually relapsing and dying of the disease. Allogenic transplant remains the best chance for cure for patients with intermediate or high risk disease. In this review, we discuss the landmark genetic studies that have improved outcome prediction and novel therapies.

Keywords: AML; leukemia; review.

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References

    1. Döhner H., Weisdorf D.J., Bloomfield C.D. Acute myeloid leukemia. N. Engl. J. Med. 2015;373:1136–1152. - PubMed
    1. Ding L., Ley T.J., Larson D.E., Miller C.A., Koboldt D.C., Welch J.S., Ritchey J.K., Young M.A., Lamprecht T., McLellan M.D., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481:506–510. doi: 10.1038/nature10738. - DOI - PMC - PubMed
    1. Campos L., Guyotat D., Archimbaud E., Devaux Y., Treille D., Larese A., Maupas J., Gentilhomme O., Ehrsam A., Fiere D. Surface marker expression in adult myeloid leukemia: Correlations with initial characteristics, morphology and response to therapy. Br. J. Haematol. 1989;72:161–166. doi: 10.1111/j.1365-2141.1989.tb07677.x. - DOI - PubMed
    1. Wolach O., Stone R.M. How I treat mixed-phenotype acute leukemia. Blood. 2015;125:2477–2485. doi: 10.1182/blood-2014-10-551465. - DOI - PubMed
    1. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., Sultan C. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 1976;33:451–458. doi: 10.1111/j.1365-2141.1976.tb03563.x. - DOI - PubMed