Acute Myeloid Leukemia: A Concise Review

doi:10.3390/jcm5030033

Review

. 2016 Mar 5;5(3):33.

doi: 10.3390/jcm5030033.

Acute Myeloid Leukemia: A Concise Review

Jennifer N Saultz¹, Ramiro Garzon²

Affiliations

¹ Medical Oncology/Hematology, Department of Internal Medicine, Starling-Loving Hall, Room M365, 320 W. 10th Ave., Columbus, OH 43210, USA. Jennifer.saultz@osumc.edu.
² Division of Hematology, Department of Internal Medicine, 460 W 12th Ave, Columbus, OH 43210, USA. ramiro.garzon@osumc.edu.

PMID: 26959069
PMCID: PMC4810104
DOI: 10.3390/jcm5030033

Review

Acute Myeloid Leukemia: A Concise Review

Jennifer N Saultz et al. J Clin Med. 2016.

. 2016 Mar 5;5(3):33.

doi: 10.3390/jcm5030033.

Authors

Jennifer N Saultz¹, Ramiro Garzon²

Affiliations

¹ Medical Oncology/Hematology, Department of Internal Medicine, Starling-Loving Hall, Room M365, 320 W. 10th Ave., Columbus, OH 43210, USA. Jennifer.saultz@osumc.edu.
² Division of Hematology, Department of Internal Medicine, 460 W 12th Ave, Columbus, OH 43210, USA. ramiro.garzon@osumc.edu.

PMID: 26959069
PMCID: PMC4810104
DOI: 10.3390/jcm5030033

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation testing remain a critical prognostic tool for post induction treatment. Despite rapid advances in the field including new drug targets and increased understanding of the biology, AML treatment remains unchanged for the past three decades with the majority of patients eventually relapsing and dying of the disease. Allogenic transplant remains the best chance for cure for patients with intermediate or high risk disease. In this review, we discuss the landmark genetic studies that have improved outcome prediction and novel therapies.

Keywords: AML; leukemia; review.

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References

1. Döhner H., Weisdorf D.J., Bloomfield C.D. Acute myeloid leukemia. N. Engl. J. Med. 2015;373:1136–1152. - PubMed
1. Ding L., Ley T.J., Larson D.E., Miller C.A., Koboldt D.C., Welch J.S., Ritchey J.K., Young M.A., Lamprecht T., McLellan M.D., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481:506–510. doi: 10.1038/nature10738. - DOI - PMC - PubMed
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1. Wolach O., Stone R.M. How I treat mixed-phenotype acute leukemia. Blood. 2015;125:2477–2485. doi: 10.1182/blood-2014-10-551465. - DOI - PubMed
1. Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., Sultan C. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 1976;33:451–458. doi: 10.1111/j.1365-2141.1976.tb03563.x. - DOI - PubMed

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[1] Döhner H., Weisdorf D.J., Bloomfield C.D. Acute myeloid leukemia. N. Engl. J. Med. 2015;373:1136–1152. - PubMed

[2] Döhner H., Weisdorf D.J., Bloomfield C.D. Acute myeloid leukemia. N. Engl. J. Med. 2015;373:1136–1152. - PubMed

[3] Ding L., Ley T.J., Larson D.E., Miller C.A., Koboldt D.C., Welch J.S., Ritchey J.K., Young M.A., Lamprecht T., McLellan M.D., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481:506–510. doi: 10.1038/nature10738. - DOI - PMC - PubMed

[4] Ding L., Ley T.J., Larson D.E., Miller C.A., Koboldt D.C., Welch J.S., Ritchey J.K., Young M.A., Lamprecht T., McLellan M.D., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012;481:506–510. doi: 10.1038/nature10738. - DOI - PMC - PubMed

[5] Campos L., Guyotat D., Archimbaud E., Devaux Y., Treille D., Larese A., Maupas J., Gentilhomme O., Ehrsam A., Fiere D. Surface marker expression in adult myeloid leukemia: Correlations with initial characteristics, morphology and response to therapy. Br. J. Haematol. 1989;72:161–166. doi: 10.1111/j.1365-2141.1989.tb07677.x. - DOI - PubMed

[6] Campos L., Guyotat D., Archimbaud E., Devaux Y., Treille D., Larese A., Maupas J., Gentilhomme O., Ehrsam A., Fiere D. Surface marker expression in adult myeloid leukemia: Correlations with initial characteristics, morphology and response to therapy. Br. J. Haematol. 1989;72:161–166. doi: 10.1111/j.1365-2141.1989.tb07677.x. - DOI - PubMed

[7] Wolach O., Stone R.M. How I treat mixed-phenotype acute leukemia. Blood. 2015;125:2477–2485. doi: 10.1182/blood-2014-10-551465. - DOI - PubMed

[8] Wolach O., Stone R.M. How I treat mixed-phenotype acute leukemia. Blood. 2015;125:2477–2485. doi: 10.1182/blood-2014-10-551465. - DOI - PubMed

[9] Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., Sultan C. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 1976;33:451–458. doi: 10.1111/j.1365-2141.1976.tb03563.x. - DOI - PubMed

[10] Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A., Gralnick H.R., Sultan C. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br. J. Haematol. 1976;33:451–458. doi: 10.1111/j.1365-2141.1976.tb03563.x. - DOI - PubMed

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Acute Myeloid Leukemia: A Concise Review

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Acute Myeloid Leukemia: A Concise Review

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