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. 2016 Mar 8;23(3):399-401.
doi: 10.1016/j.cmet.2016.02.017.

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

Chen-Song Zhang  1 , Sheng-Cai Lin  2
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AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

Chen-Song Zhang et al. Cell Metab. .
Free article

Abstract

AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.

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