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Observational Study
. 2016 Mar 27;30(6):899-908.
doi: 10.1097/QAD.0000000000001005.

CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy

Jessica L Castilho  1 , Bryan E Shepherd, John Koethe, Megan Turner, Sally Bebawy, James Logan, William B Rogers, Stephen Raffanti, Timothy R Sterling
Affiliations
Observational Study

CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy

Jessica L Castilho et al. AIDS. .

Abstract

Objective: In virologically suppressed HIV-infected adults, noncommunicable diseases (NCDs) have been associated with immune senescence and low CD4/CD8 lymphocyte ratio. Age differences in the relationship between CD4/CD8 ratio and NCDs have not been described.

Design: Observational cohort study.

Methods: We assessed CD4/CD8 ratio and incident NCDs (cardiovascular, cancer, liver, and renal diseases) in HIV-infected adults started on antiretroviral therapy between 1998 and 2012. Study inclusion began once patients maintained virologic suppression for 12 months (defined as baseline). We examined age and baseline CD4/CD8 ratio and used Cox proportional hazard models to assess baseline CD4/CD8 ratio and NCDs.

Results: This study included 2006 patients. Low baseline CD4/CD8 ratio was associated with older age, male sex, and low CD4 lymphocyte counts. In models adjusting for CD4 lymphocyte count, CD4/CD8 ratio was inversely associated with age (P < 0.01). Among all patients, 182 had incident NCDs, including 46 with coronary artery disease (CAD) events. CD4/CD8 ratio was inversely associated with risk of CAD events [adjusted HR per 0.1 increase in CD4/CD8 ratio = 0.87, 95% confidence interval (CI): 0.76-0.99, P = 0.03]. This association was driven by those under age 50 years (adjusted HR 0.83 [0.70-0.97], P = 0.02) vs. those over age 50 years (adjusted HR = 0.96 [0.79-1.18], P = 0.71). CD4/CD8 ratio was not significantly associated with incident noncardiac NCDs.

Conclusions: Higher CD4/CD8 ratio after 1 year of HIV virologic suppression was independently predictive of decreased CAD risk, particularly among younger adults. Advanced immune senescence may contribute to CAD events in younger HIV patients on antiretroviral therapy.

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Figures

Figure 1
Figure 1. Trends in CD4/CD8 ratio (A) and change in CD4/CD8 ratio by age (B), stratified by baseline CD4 lymphocyte count
Figure 2
Figure 2. Baseline CD4/CD8 ratio of patients by NCD outcomes
Median values and IQR shown by box plots. P values reflect comparison with CD4/CD8 ratio among patients without any NCD events.
Figure 3
Figure 3. Cumulative incidence of NCD outcomes by baseline CD4/CD8 ratio category
Death was used as the competing event to calculate cumulative incidence.
See this image and copyright information in PMC

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