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Review
. 2016 Sep;20(9):1099-108.
doi: 10.1517/14728222.2016.1164693. Epub 2016 Mar 21.

Mir-221/222 are promising targets for innovative anticancer therapy

Maria Teresa Di Martino  1 , Marco Rossi  1 , Daniele Caracciolo  1 , Annamaria Gullà  1 , Pierosandro Tagliaferri  1 , Pierfrancesco Tassone  1   2
Affiliations
Review

Mir-221/222 are promising targets for innovative anticancer therapy

Maria Teresa Di Martino et al. Expert Opin Ther Targets. 2016 Sep.

Abstract

Introduction: MicroRNAs (miRNAs) are key non-coding RNA post-transcriptional regulators of messenger RNAs (mRNAs), and are deeply dysregulated in human cancer. A rising body of evidence indicates that miRNAs represent valuable therapeutic targets. In this light, the cluster miR-221/222 are of particular relevance, given that they are strongly upregulated in a variety of solid and hematologic malignancies.

Area covered: This review summarizes recent findings on the roles played by miR-221/222 in human cancer and their potential clinical value as promising targets for therapeutic studies.

Expert opinion: The rising body of advanced preclinical evidence on the biological significance of miR-221/222 in a variety of malignancies indicates that they will play a crucial role in the future of innovative therapeutic strategies, both as validated biomarkers and targets.

Keywords: MicroRNA; cancer; miR-221; miR-221/222; miRNA; miRNA inhibitors; myeloma; oligonucleotide-based therapy.

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