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. 2016 May;62(5):676-8.
doi: 10.1373/clinchem.2015.251181. Epub 2016 Mar 9.

Can Metabolic Profiles Be Used as a Phenotypic Readout of the Genome to Enhance Precision Medicine?

Kévin Contrepois  1 , Liang Liang  1 , Michael Snyder  2
Affiliations

Can Metabolic Profiles Be Used as a Phenotypic Readout of the Genome to Enhance Precision Medicine?

Kévin Contrepois et al. Clin Chem. 2016 May.
No abstract available

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Conflict of interest statement

Authors’ Disclosures or Potential Conflicts of Interest: Upon manuscript submission, all authors completed the author disclosure form. Disclosures and/or potential conflicts of interest:

Figures

Fig. 1
Fig. 1. Combination of personal genetic information and metabolic profiles for precision medicine
Static DNA sequences inform on inherited genetic variations, whereas dynamic metabolites—influenced by the environment and the microbiome—give access to the phenotypic readout of the genome. After defining an individual health baseline, regular metabolome measurements (indicated by the multiple green down arrows) allow health monitoring as well as disease risk prediction and can result in nutrition/lifestyle recommendations to prevent the onset of a disease or increase the efficiency of drug treatments.
See this image and copyright information in PMC

References

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