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Comment
. 2016 Apr;13(4):185-6.
doi: 10.1038/nrcardio.2016.35. Epub 2016 Mar 10.

Heart failure: SGLT2 inhibitors and heart failure -- clinical implications

Itamar Raz  1 , Avivit Cahn  1
Affiliations
Comment

Heart failure: SGLT2 inhibitors and heart failure -- clinical implications

Itamar Raz et al. Nat Rev Cardiol. 2016 Apr.

Abstract

The latest findings from the EMPA-REG OUTCOME trial show a 34% reduction in hospitalization for heart failure or cardiovascular death in patients receiving empagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor, compared with placebo. These outstanding results call for discussion of the clinical implications, and in-depth studies of the mechanisms of action of SGLT2 inhibitors.

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