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Review
. 2016 Apr 29;90(10):4864-4875.
doi: 10.1128/JVI.00252-16. Print 2016 May 15.

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

Helen M Lazear  1 , Michael S Diamond  2
Affiliations
Review

Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

Helen M Lazear et al. J Virol. .

Abstract

Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.

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Figures

FIG 1
FIG 1
Schematic phylogeny illustrating the genetic relationships between selected flaviviruses that are human pathogens. The dendrogram (145) is based on the amino acid sequence of the complete polyprotein.
FIG 2
FIG 2
ZIKV pathogenesis. The typical course of ZIKV infection is illustrated (green background), with potential severe effects requiring further investigation indicated (blue background). DENV, dengue virus; ADE, antibody-dependent enhancement.
See this image and copyright information in PMC

References

    1. Pierson TC, Diamond MS. 2013. Flaviviruses, p 747–794. In Knipe DM, Howley PM (ed), Fields virology, 6th ed, vol 2 Wolter Kluwer.
    1. Gatherer D, Kohl A. 2016. Zika virus: a previously slow pandemic spreads rapidly through the Americas. J Gen Virol 97:269–273. doi: 10.1099/jgv.0.000381. - DOI - PubMed
    1. Chambers TJ, Hahn CS, Galler R, Rice CM. 1990. Flavivirus genome organization, expression, and replication. Annu Rev Microbiol 44:649–688. doi: 10.1146/annurev.mi.44.100190.003245. - DOI - PubMed
    1. Kuno G, Chang GJ. 2007. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol 152:687–696. doi: 10.1007/s00705-006-0903-z. - DOI - PubMed
    1. Mukhopadhyay S, Kuhn RJ, Rossmann MG. 2005. A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 3:13–22. doi: 10.1038/nrmicro1067. - DOI - PubMed

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