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. 2016 Jan 29:5:9.
doi: 10.4103/2277-9175.175242. eCollection 2016.

Common antigens between hydatid cyst and cancers

Shima Daneshpour  1 , Mehran Bahadoran  2 , Seyed Hossein Hejazi  2 , Abas Ali Eskandarian  2 , Mehdi Mahmoudzadeh  3 , Hossein Yousofi Darani  2
Affiliations

Common antigens between hydatid cyst and cancers

Shima Daneshpour et al. Adv Biomed Res. .

Abstract

Background: Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydatid cyst. This common antigen may be involved in the effect of parasite on cancer growth. So in this work, common antigens between hydatid cyst and cancers have been investigated.

Materials and methods: Different hydatid cyst antigens including hydatid fluid, laminated and germinal layer antigens, and excretory secretory antigens of protoscolices were run in SDS PAGE and transferred to NCP paper. In western immunoblotting, those antigens were probed with sera of patients with different cancer and also sera of non-cancer patients. Also, cross reaction among excretory secretory products of cancer cells and antisera raised against different hydatid cyst antigen was investigated.

Results: In western immunoblotting, antisera raised against laminated and germinal layers of hydatid cyst reacted with excretory secretory products of cancer cells. Also, a reaction was detected between hydatid cyst antigens and sera of patients with some cancers.

Conclusion: Results of this work emphasize existence of common antigens between hydatid cyst and cancers. More investigation about these common antigens is recommended.

Keywords: Cancer; common antigen; hydatid cyst.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures

Figure 1
Figure 1
Western immunoblotting of hydatid cyst fluid antigen probed with (from left) normal sera, sera of patients with breast cancer and a patient serum with hydatid cyst
Figure 2
Figure 2
Western immunoblotting of cancer cells ES antigens probed with the sera of rabbits raised against hydatid cyst Laminated and germial layers antigen (both lanes)
See this image and copyright information in PMC

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