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Comment
. 2016 Mar 9;19(3):275-6.
doi: 10.1016/j.chom.2016.02.018.

A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV

Anna Licht  1 , Galit Alter  2
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Free article
Comment

A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV

Anna Licht et al. Cell Host Microbe. .
Free article

Abstract

Understanding where and how the HIV latent reservoir persists is essential for developing rational HIV cure strategies. In a recent paper in Nature, Lorenzo-Redondo et al. (2016) demonstrate that HIV persists and actively evolves within lymph nodes due to low antiretroviral drug penetration, revealing the need to target these drug-privileged sites.

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  • Persistent HIV-1 replication maintains the tissue reservoir during therapy.
    Lorenzo-Redondo R, Fryer HR, Bedford T, Kim EY, Archer J, Pond SLK, Chung YS, Penugonda S, Chipman J, Fletcher CV, Schacker TW, Malim MH, Rambaut A, Haase AT, McLean AR, Wolinsky SM. Lorenzo-Redondo R, et al. Nature. 2016 Feb 4;530(7588):51-56. doi: 10.1038/nature16933. Epub 2016 Jan 27. Nature. 2016. PMID: 26814962 Free PMC article.

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