Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Apr;22(4):269-271.
doi: 10.1016/j.molmed.2016.02.008. Epub 2016 Mar 7.

An Intestinal Inflammasome - The ILC3-Cytokine Tango

Pedro Gonçalves  1 , James P Di Santo  2
Affiliations
Comment

An Intestinal Inflammasome - The ILC3-Cytokine Tango

Pedro Gonçalves et al. Trends Mol Med. 2016 Apr.

Abstract

The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.

Keywords: IL-18; IL-22; inflammasome; innate lymphoid cells; metabolites; microbiota.

PubMed Disclaimer

Comment on

Publication types

MeSH terms

LinkOut - more resources