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Comment
. 2016 Mar 22;113(12):3133-5.
doi: 10.1073/pnas.1602568113. Epub 2016 Mar 10.

Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove

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Comment

Cardiac myosin-binding protein C: A protein once at loose ends finds its regulatory groove

Richard L Moss. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) Electron micrograph of cardiac sarcomere showing symmetrically localized transverse stripes corresponding to cMyBP-C in the C zone of the thick filaments (13). (B) Diagram of molecular structure of cMyBP-C (1).

Comment on

References

    1. Moss RL, Fitzsimons DP, Ralphe JC. Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium. Circ Res. 2015;116(1):183–192. - PMC - PubMed
    1. Hartzell HC. Effects of phosphorylated and unphosphorylated C-protein on cardiac actomyosin ATPase. J Mol Biol. 1985;186(1):185–195. - PubMed
    1. Weisberg A, Winegrad S. Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle. Proc Natl Acad Sci USA. 1996;93(17):8999–9003. - PMC - PubMed
    1. Gautel M, Zuffardi O, Freiburg A, Labeit S. Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: A modulator of cardiac contraction? EMBO J. 1995;14(9):1952–1960. - PMC - PubMed
    1. Shaffer JF, Kensler RW, Harris SP. The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner. J Biol Chem. 2009;284(18):12318–12327. - PMC - PubMed

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