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. 2016 Mar;14(1):12-7.
doi: 10.1016/j.aju.2015.11.004. Epub 2015 Dec 31.

Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study

Hazem Elgalaly  1 , Ahmed Sakr  1 , Amr Fawzi  1 , Emad A Salem  1 , Esam Desoky  1 , Ashraf Shahin  1 , Mostafa Kamel  1
Affiliations

Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study

Hazem Elgalaly et al. Arab J Urol. 2016 Mar.

Abstract

Objectives: To compare the efficacy of silodosin (8 mg) vs tamsulosin (0.4 mg), as a medical expulsive therapy, in the management of distal ureteric stones (DUS) in terms of stone clearance rate and stone expulsion time.

Patients and methods: A prospective randomised study was conducted on 115 patients, aged 21-55 years, who had unilateral DUS of ⩽10 mm. Patients were divided into two groups. Group 1 received silodosin (8 mg) and Group 2 received tamsulosin (0.4 mg) daily for 1 month. The patients were followed-up by ultrasonography, plain abdominal radiograph of the kidneys, ureters and bladder, and computed tomography (in some cases).

Results: There was a significantly higher stone clearance rate of 83% in Group 1 vs 57% in Group 2 (P = 0.007). Group 1 also showed a significant advantage for stone expulsion time and analgesic use. Four patients, two in each group, discontinued the treatment in first few days due to side-effects (orthostatic hypotension). No severe complications were recorded during the treatment period. Retrograde ejaculation was recorded in nine and three patients in Groups 1 and 2, respectively.

Conclusion: Our data show that silodosin is more effective than tamsulosin in the management of DUS for stone clearance rates and stone expulsion times. A multicentre study on larger scale is needed to confirm the efficacy and safety of silodosin.

Keywords: DUS, distal ureteric stones; Distal; KUB, plain abdominal radiograph of the kidneys, ureters and bladder; MET, medical expulsive therapy; SWL, shockwave lithotripsy; Silodosin; Stone; Tamsulosin; Ureteric.

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Figures

Figure 1
Figure 1
Flowchart of the study design. ttt, treat-to-target.
Figure 2
Figure 2
Kaplan–Meier function curve.
See this image and copyright information in PMC

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