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. 2016 Apr 22;79(4):1203-7.
doi: 10.1021/acs.jnatprod.5b01130. Epub 2016 Mar 11.

Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton

Xiao-Hui Li  1   2 , Yu Zhang  1 , Jia-Hui Zhang  1 , Xiao-Nian Li  1 , Ming-Ming Cao  1 , Ying-Tong Di  1 , Zong-Gen Peng  3 , Jian-Dong Jiang  3 , Xiao-Jiang Hao  1
Affiliations

Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton

Xiao-Hui Li et al. J Nat Prod. .

Abstract

Myritonines A-C (1-3), three new alkaloids bearing an unprecedented heterohexacyclic skeleton, were isolated from Myrioneuron tonkinensis. Their structures were determined by a combination of spectroscopic data and single-crystal X-ray diffraction analysis. Compound 3 represents the first Myrioneuron alkaloid featuring a unique trans-decahydroquinoline motif and was also found to possess a rare cyano functionality. Compounds 1 and 2 showed inhibition against the hepatitis C virus in vitro.

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