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. 2016 Mar 11:15:54.
doi: 10.1186/s12944-016-0224-5.

SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Nasser M Al-Daghri  1   2 , Abdul Khader Mohammed  3   4 , Omar S Al-Attas  3   4 , Osama E Amer  3   4 , Mario Clerici  5 , Amal Alenad  6 , Majed S Alokail  3   4
Affiliations

SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Nasser M Al-Daghri et al. Lipids Health Dis. .

Abstract

Background: Irisin is a recently identified myokine that plays an important role in preventing obesity and insulin resistance. We investigated whether the common FNDC5 (irisin precursor) gene variants influence susceptibility to obesity and type 2 diabetes (T2D) and verified the impact of FNDC5 gene variants on serum irisin levels, glucose and lipid metabolism in a Saudi population.

Methods: Genomic DNA from 814 (394 T2DM and 414 controls) subjects were genotyped for the five common SNPs (rs3480A/G, rs1746661G/T, rs1298190A/G, rs726344A/G and rs1570569G/T) of the FNDC5 gene using the TaqMan genotyping assay. Biochemical parameters and hematic concentrations of irisin and insulin as well as anthropometric indices were collected.

Results: Serum irisin levels were higher in T2DM patients compared to controls (p < 0.0001). Analyses of FNDC5 SNPs showed that: 1) The rs3480 GG associates with decreased risk of obesity (p = 0.005; odds ratio: 0.48) and lower body mass index (BMI) values (p = 0.03). In addition, GGAAG was identified as the protective haplotype against risk of obesity (p = 0.001; odds ratio: 0.23). 2) The rs1746661 G allele associates with higher triglyceride (TG) levels (p = 0.019). 3) The rs157069 TT genotype associates with higher fasting insulin (p = 0.029) and HOMA-IR (p = 0.002) as well as with lower circulating irisin levels (p = 0.016).

Conclusions: SNPs in FNDC5 gene correlates with obesity and glucose-lipid metabolism possibly because they modulate the serum levels of irisin.

Keywords: Insulin; Irisin; Obesity; SNPs; Triglyceride; Type 2 diabetes.

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Figures

Fig. 1
Fig. 1
a Median circulating irisin levels in T2DM vs Non-T2DM group. b Median circulating irisin levels in obese vs lean group. Results are shown as median values for each group
See this image and copyright information in PMC

References

    1. Højlund K, Boström P. Irisin in obesity and type 2 diabetes. J Diabetes Complications. 2012;27:303–4. doi: 10.1016/j.jdiacomp.2013.04.002. - DOI - PubMed
    1. Hotta K, Kitamoto A, Kitamoto T, Mizusawa S, Teranishi H, So R, et al. Replication study of 15 recently published Loci for body fat distribution in the Japanese population. J Atheroscler Thromb. 2012;20:336–50. doi: 10.5551/jat.14589. - DOI - PubMed
    1. Villarejo C, Fernández‐Aranda F, Jiménez‐Murcia S, Peñas‐Lledó E, Granero R, Penelo E, et al. Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates. Eur Eat Disord Rev. 2012;20:250–4. doi: 10.1002/erv.2166. - DOI - PMC - PubMed
    1. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Vinodson B, et al. Maternal inheritance of circulating irisin in humans. Clin Sci. 2014;126:837-44. - PubMed
    1. Reinehr T, Elfers C, Lass N, Roth CL. Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis. J Clin Endocrinol Metab. 2015;100:2123–30. doi: 10.1210/jc.2015-1208. - DOI - PubMed

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