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Review
. 2016 Jul;308(5):287-96.
doi: 10.1007/s00403-016-1638-7. Epub 2016 Mar 11.

Interleukin-33: increasing role in dermatological conditions

Anna Balato  1 , Annunziata Raimondo  2 , Nicola Balato  2 , Fabio Ayala  2 , Serena Lembo  2
Affiliations
Review

Interleukin-33: increasing role in dermatological conditions

Anna Balato et al. Arch Dermatol Res. 2016 Jul.

Abstract

Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan IL-1 family receptor. Interleukin-33/ST2 signaling has been studied in a wide range of inflammatory skin conditions for its crucial role in immune responses and tissue homeostasis. In this review, we report the current knowledge regarding the complex biology of interleukin-33 and its function in the skin and in clinical settings.

Keywords: IL-33; Immunity; ST2; Skin diseases.

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