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Review
. 2016:117:671-95.
doi: 10.1016/bs.ctdb.2015.11.021. Epub 2016 Jan 21.

The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?

Sarah J L Graham  1 , Magdalena Zernicka-Goetz  2
Affiliations
Review

The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?

Sarah J L Graham et al. Curr Top Dev Biol. 2016.

Abstract

Specification of cell fate in the early mouse embryo involves the generation of heterogeneities between cells in polarity, position, gene expression, and protein activity. Identifying when and how these differences first become established represents an important challenge for understanding the roles of stochastic and cell history-dependent mechanisms in mammalian development.

Keywords: Blastocyst; Cell fate; Differentiation; Mouse embryo; Pluripotency; Preimplantation.

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