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Review
. 2016 Nov;71(11):1513-1525.
doi: 10.1111/all.12880. Epub 2016 Aug 23.

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

J Bousquet  1   2   3 , J M Anto  4   5   6   7 , M Akdis  8 , C Auffray  9 , T Keil  10   11 , I Momas  12   13 , D S Postma  14 , R Valenta  15 , M Wickman  16 , A Cambon-Thomsen  17 , T Haahtela  18 , B N Lambrecht  19 , K C Lodrup Carlsen  20 , G H Koppelman  21 , J Sunyer  4   5   6   7 , T Zuberbier  22 , I Annesi-Maesano  23 , A Arno  24 , C Bindslev-Jensen  25 , G De Carlo  26 , F Forastiere  27 , J Heinrich  28 , M L Kowalski  29 , D Maier  30 , E Melén  14   31 , S Palkonen  26 , H A Smit  32 , M Standl  28 , J Wright  33 , A Asarnoj  34   35 , M Benet  4 , N Ballardini  16   36 , J Garcia-Aymerich  4   5   6   7 , U Gehring  37 , S Guerra  4 , C Hohman  38 , I Kull  16   39 , C Lupinek  15 , M Pinart  4 , I Skrindo  20 , M Westman  40   41 , D Smagghe  42 , C Akdis  8 , R Albang  30 , V Anastasova  17 , N Anderson  43 , C Bachert  44 , S Ballereau  9 , F Ballester  45 , X Basagana  4 , A Bedbrook  46 , A Bergstrom  43 , A von Berg  47 , B Brunekreef  32 , E Burte  48 , K H Carlsen  49 , L Chatzi  50 , J M Coquet  19 , M Curin  15 , P Demoly  51 , E Eller  25 , M P Fantini  52 , B Gerhard  30 , H Hammad  19 , L von Hertzen  18 , V Hovland  49 , B Jacquemin  4 , J Just  53 , T Keller  38 , M Kerkhof  14 , R Kiss  15 , M Kogevinas  4   5   6   7 , S Koletzko  54 , S Lau  55 , I Lehmann  56 , N Lemonnier  9 , R McEachan  33 , M Mäkelä  18 , J Mestres  57 , E Minina  30 , P Mowinckel  49 , R Nadif  48 , M Nawijn  21 , S Oddie  33 , J Pellet  9 , I Pin  58 , D Porta  27 , F Rancière  12 , A Rial-Sebbag  17 , Y Saeys  19 , M J Schuijs  19 , V Siroux  59 , C G Tischer  28 , M Torrent  4   60 , R Varraso  48 , J De Vocht  26 , K Wenger  30 , S Wieser  15 , C Xu  14
Affiliations
Review

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015

J Bousquet et al. Allergy. 2016 Nov.

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Keywords: IgE; asthma; multimorbidity; polysensitization; rhinitis.

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Figures

Figure 1
Figure 1
Prevalence* of symptoms of asthma, rhinitis and eczema according to the two groups identified in cluster analysis, at 4 and 8 years (Garcia‐Aymerich et al. 42).
Figure 2
Figure 2
MeDALL interactions between EU and WHO (from Ref. 74). GARD, Global Alliance against Chronic Respiratory Diseases; NGO, nongovernmental organization; GO, governmental organization; MOH, Ministry of Health; NCD, noncommunicable disease.
See this image and copyright information in PMC

References

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