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Review
. 2016 Aug;283(16):3002-15.
doi: 10.1111/febs.13709. Epub 2016 Apr 1.

The JAK/STAT pathway in obesity and diabetes

Esteban N Gurzov  1   2 , William J Stanley  1   2 , Evan G Pappas  1   2 , Helen E Thomas  1   2 , Daniel J Gough  3   4
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Free article
Review

The JAK/STAT pathway in obesity and diabetes

Esteban N Gurzov et al. FEBS J. 2016 Aug.
Free article

Abstract

Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT signaling pathway is required for normal homeostasis, and, when dysregulated, contributes to the development of obesity and diabetes. In this review, we analyze the role of JAK/STAT activation in the brain, liver, muscle, fat and pancreas, and how this affects the course of the disease. We also consider the therapeutic implications of targeting the JAK/STAT pathway in treatment of obesity and diabetes.

Keywords: JAK/STAT signaling pathway; adipose tissue; brain; cytokines; diabetes; hormones; liver; muscle; obesity; pancreas.

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