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. 2015 Dec 22;6(6):1000341.
doi: 10.4172/2155-9562.1000341.

Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke

Monica C Serra  1 , Charlene E Hafer-Macko  2 , Alice S Ryan  1
Affiliations

Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke

Monica C Serra et al. J Neurol Neurophysiol. .

Abstract

Objective: Resting metabolic rate (RMR) is the component of energy expenditure that explains the largest proportion of total daily energy requirements. Since RMR is determined largely by fat-free mass and a low RMR predicts weight gain in healthy adults, identifying the role of muscle atrophy following stroke on RMR may help identify ways to mitigate the development of obesity post-stroke.

Methods: Thirty-nine stroke survivors with chronic hemiparesis (mean ± SEM: age: 61 ± 1 years, latency from stroke: 107 ± 40 months, BMI: 31 ± 3 kg/m2) underwent DXA scans for measurement of body composition, including total, paretic, and non-paretic leg lean mass and fasted, 30-min indirect calorimetry for measurement of RMR.

Result: Predicted RMR was calculated by the Mifflin-St Jeor equation, which considers weight, height, and age for both men and women. RMR was 14% lower than predicted (1438 ± 45 vs. 1669 ± 38 kcals/24 hrs; P<0.01). Total (r=0.73, P<0.01), paretic (r=0.72, P<0.01) and non-paretic (r=0.67, P<0.01) leg lean mass predicted RMR.

Conclusion: These data indicate that muscle atrophy post stroke may lead to a reduced RMR. This substantiates the need to attenuate the loss of lean mass after a stroke to prevent declines in RMR and possible weight gain common post-stroke.

Keywords: Chronic stroke; Resting metabolic rate; Weight management.

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Figures

Figure 1
Figure 1
Resting metabolic rate (measured by indirect calorimetry) is 14% below predicted (using Mifflin-St Jeor equation) in chronic stroke survivors with hemiparesis (P<0.01).
Figure 2
Figure 2
Total leg lean predicts RMR in stroke survivors with hemiparesis (r=0.73, P<0.01).
See this image and copyright information in PMC

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References

    1. American Heart Association I. Older Americans & Cardiovascular Diseases. Statistical Fact Sheet. 2013 Update.
    1. Ryan AS, Dobrovolny CL, Smith GV, Silver KH, Macko RF. Hemiparetic muscle atrophy and increased intramuscular fat in stroke patients. Arch Phys Med Rehabil. 2002;83:1703–1707. - PubMed
    1. Ryan AS, Buscemi A, Forrester L, Hafer-Macko CE, Ivey FM. Atrophy and intramuscular fat in specific muscles of the thigh: associated weakness and hyperinsulinemia in stroke survivors. Neurorehabilitation and neural repair. 2011;25:865–872. - PMC - PubMed
    1. Tsur A, Segal Z. Falls in stroke patients: risk factors and risk management. Isr Med Assoc J. 2010;12:216–219. - PubMed
    1. Kim O, Kim JH. Falls and Use of Assistive Devices in Stroke Patients with Hemiparesis: Association with Balance Ability and Fall Efficacy. Rehabil Nurs. 2015;40:267–274. - PubMed

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