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. 2015 Dec 22;6(6):1000341.
doi: 10.4172/2155-9562.1000341.

Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke

Monica C Serra  1 , Charlene E Hafer-Macko  2 , Alice S Ryan  1
Affiliations

Reduced Resting Metabolic Rate in Adults with Hemiparetic Chronic Stroke

Monica C Serra et al. J Neurol Neurophysiol. .

Abstract

Objective: Resting metabolic rate (RMR) is the component of energy expenditure that explains the largest proportion of total daily energy requirements. Since RMR is determined largely by fat-free mass and a low RMR predicts weight gain in healthy adults, identifying the role of muscle atrophy following stroke on RMR may help identify ways to mitigate the development of obesity post-stroke.

Methods: Thirty-nine stroke survivors with chronic hemiparesis (mean ± SEM: age: 61 ± 1 years, latency from stroke: 107 ± 40 months, BMI: 31 ± 3 kg/m2) underwent DXA scans for measurement of body composition, including total, paretic, and non-paretic leg lean mass and fasted, 30-min indirect calorimetry for measurement of RMR.

Result: Predicted RMR was calculated by the Mifflin-St Jeor equation, which considers weight, height, and age for both men and women. RMR was 14% lower than predicted (1438 ± 45 vs. 1669 ± 38 kcals/24 hrs; P<0.01). Total (r=0.73, P<0.01), paretic (r=0.72, P<0.01) and non-paretic (r=0.67, P<0.01) leg lean mass predicted RMR.

Conclusion: These data indicate that muscle atrophy post stroke may lead to a reduced RMR. This substantiates the need to attenuate the loss of lean mass after a stroke to prevent declines in RMR and possible weight gain common post-stroke.

Keywords: Chronic stroke; Resting metabolic rate; Weight management.

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Figures

Figure 1
Figure 1
Resting metabolic rate (measured by indirect calorimetry) is 14% below predicted (using Mifflin-St Jeor equation) in chronic stroke survivors with hemiparesis (P<0.01).
Figure 2
Figure 2
Total leg lean predicts RMR in stroke survivors with hemiparesis (r=0.73, P<0.01).
See this image and copyright information in PMC

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