Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May;48(5):497-9.
doi: 10.1038/ng.3527. Epub 2016 Mar 14.

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

Peter Huypens  1   2   3 , Steffen Sass  4 , Moya Wu  1   2 , Daniela Dyckhoff  1   2   3 , Matthias Tschöp  3   5   6 , Fabian Theis  4   7 , Susan Marschall  1   2 , Martin Hrabě de Angelis  1   2   3   8 , Johannes Beckers  1   2   3   8
Affiliations

Epigenetic germline inheritance of diet-induced obesity and insulin resistance

Peter Huypens et al. Nat Genet. 2016 May.

Abstract

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

PubMed Disclaimer

Comment in

References

    1. Diabetes. 2012 Nov;61(11):2833-41 - PubMed
    1. Horm Behav. 2011 Mar;59(3):306-14 - PubMed
    1. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R528-38 - PubMed
    1. Diabetologia. 2015 Mar;58(3):615-24 - PubMed
    1. Arch Dis Child. 1997 Nov;77(5):376-81 - PubMed

Publication types