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. 2016 Apr;57(Pt A):202-210.
doi: 10.1016/j.yebeh.2016.02.002. Epub 2016 Mar 12.

Predictors of trajectories of epilepsy-specific quality of life among children newly diagnosed with epilepsy

Rachelle R Ramsey  1 , Kristin Loiselle  1 , Joseph R Rausch  1 , Jordan Harrison  2 , Avani C Modi  3
Affiliations

Predictors of trajectories of epilepsy-specific quality of life among children newly diagnosed with epilepsy

Rachelle R Ramsey et al. Epilepsy Behav. 2016 Apr.

Abstract

Objective: The objective of this study was to identify two-year trajectories of epilepsy-specific health-related quality of life (HRQOL) among children newly diagnosed with epilepsy and to evaluate the predictive value of a comprehensive set of medical, psychosocial, and family factors.

Methods: Ninety-four children with epilepsy (8.14 ± 2.37 years of age and 63% male) and their caregivers participated in this study. Caregivers completed the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) and measures of psychological and family functioning at one month postdiagnosis. The QOLCE was also given at eight additional time points during the subsequent two years as a part of a large observational study in children with epilepsy. Adherence data were collected via MEMS TrackCaps, and medical information was collected through chart review.

Results: Unique trajectories were identified for the overall QOLCE scale, as well as the subscales. Most trajectory models for the QOLCE subscales contained at least one at-risk trajectory for children, indicating that there is a subgroup of children experiencing poor long-term HRQOL. Health-related quality-of-life trajectories remained predominantly stable during the two-year period following treatment initiation. The number of AEDs, internalizing problems, and externalizing problems emerged as the most consistent predictors across the HRQOL domains.

Significance: Medical and psychosocial interventions, such as cognitive-behavioral strategies, should target modifiable factors (e.g., internalizing symptoms, externalizing symptoms, number of AEDs trialed) shortly after diagnosis to improve HRQOL for children with epilepsy over the course of their disease.

Keywords: Children; Epilepsy; Quality of life; Trajectories.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts to disclose.

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References

    1. FDA. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance. Health & Quality of Life Outcomes. 2006;4:79–20. - PMC - PubMed
    1. Varni JW, Burwinkle TM, Seid M, Skarr D. The PedsQL 4. 0 as a pediatric population health measure: feasibility, reliability, and validity. Ambul Pediatr. 2003;3:329–41. - PubMed
    1. Speechley KN, Ferro MA, Camfield CS, Huang W, Levin SD, Smith ML, Wiebe S, Zou G. Quality of life in children with new-onset epilepsy A 2-year prospective cohort study. Neurology. 2012;79:1548–1555. - PMC - PubMed
    1. Modi AC, King AS, Monahan SR, Koumoutsos JE, Morita DA, Glauser TA. Even a single seizure negatively impacts pediatric health-related quality of life. Epilepsia. 2009;50:2110–6. - PubMed
    1. Dunn DW, Austin JK, Harezlak J, Ambrosius WT. ADHD and epilepsy in childhood. Dev Med Child Neurol. 2003;45:50–4. - PubMed

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