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. 2016 Apr 22;79(4):784-91.
doi: 10.1021/acs.jnatprod.5b00810. Epub 2016 Mar 14.

Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa

Nuraqilah Othman  1 , Li Pan  2 , Michele Mejin  1 , Julian C L Voong  1 , Hee-byung Chai  2 , Caroline M Pannell  3 , A Douglas Kinghorn  2 , Tiong C Yeo  1
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Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa

Nuraqilah Othman et al. J Nat Prod. .

Abstract

Four new 2,3-secodammarane triterpenoids, stellatonins A-D (3-6), together with a new 3,4-secodammarane triterpenoid, stellatonin E (7), and the known silvestrol (1), 5‴-episilvestrol (2), and β-sitosterol, were isolated from a methanol extract of the stems of Aglaia stellatopilosa through bioassay-guided fractionation. The structures of the new compounds were elucidated using spectroscopic and chemical methods. The compounds were evaluated for their cytotoxic activity against three human cancer cell lines and for their antimicrobial activity using a microtiter plate assay against a panel of Gram-positive and Gram-negative bacteria and fungi.

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Figures

Figure 1
Figure 1
Selected key COSY (bold lines), HMBC ( formula image) and NOESY ( formula image) correlations of 3, 4, 6, and 7.
Figure 2
Figure 2
ΔδS-R values of MTPA esters of 3.
See this image and copyright information in PMC

References

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