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Case Reports
. 2016 Dec;32(12):1577.e9-1577.e11.
doi: 10.1016/j.cjca.2015.12.034. Epub 2016 Jan 15.

Management of Loeffler's Endocarditis With Bivalvular Involvement and a FIP1L1/PDGFRA-Negative Mutation

Mario Sénéchal  1 , Pierre-Louis Bernard  2 , Stéphanie Cloutier  2 , Marie-Hélène Leblanc  2 , Éric Larose  2 , Alexandre Cinq-Mars  2 , Michelle Dubois  2
Affiliations
Case Reports

Management of Loeffler's Endocarditis With Bivalvular Involvement and a FIP1L1/PDGFRA-Negative Mutation

Mario Sénéchal et al. Can J Cardiol. 2016 Dec.

Abstract

Hypereosinophilic syndromes (HESs) are a group of disorders characterized by end-organ damage caused by eosinophilic infiltration. We present a patient with idiopathic HES with severe tricuspid and mitral regurgitation secondary to Loeffler's endocarditis. In addition to prednisone, imatinib therapy initially helped control the eosinophil count. However, successful long-term remission was achieved with hydroxyurea therapy.

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