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. 2016 Nov;20(5):302-6.
doi: 10.22045/ibj.2016.08. Epub 2016 May 25.

Demonstration of Herpes Simplex Virus, Cytomegalovirus, and Epstein-Barr Virus in Colorectal Cancer

Sahar Mehrabani-Khasraghi  1 , Mitra Ameli  2 , Farzad Khalily  3
Affiliations

Demonstration of Herpes Simplex Virus, Cytomegalovirus, and Epstein-Barr Virus in Colorectal Cancer

Sahar Mehrabani-Khasraghi et al. Iran Biomed J. 2016 Nov.

Abstract

Background: The present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (HSV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in CRC and colorectal polyp by using the PCR method in Iran.

Methods: In this analytical case-control study, we selected 15 patients with CRC, 20 patients with colorectal polyp, and 35 patients without malignancy as controls. After DNA extraction, PCR was used to determine HSV, CMV, and EBV genome by specific primers. Statistical analysis was performed using χ2 tests.

Results: Our findings demonstrated that there is no direct molecular evidence to support the association between HSV, CMV, and EBV and human colorectal malignancies.

Conclusion: The results from this study do not exclude a possible oncogenic role of these viruses in neoplastic development of colon cells.

Keywords: Colorectal cancer; Cytomegalovirus; Epstein-Bar virus; Herpes simplex virus; PCR.

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Conflict of interest statement

CONFLICT OF INTEREST. None declared.

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