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. 2016 Jun:33:100-5.
doi: 10.1016/j.jcrc.2016.02.005. Epub 2016 Feb 15.

Coupled plasma filtration adsorption improves hemodynamics in septic shock

Matteo Franchi  1 , Marilù Giacalone  2 , Ippolito Traupe  3 , Rocco Rago  4 , Giacomo Baldi  5 , Francesco Giunta  6 , Francesco Forfori  7
Affiliations

Coupled plasma filtration adsorption improves hemodynamics in septic shock

Matteo Franchi et al. J Crit Care. 2016 Jun.

Abstract

Purpose: Septic shock involves a dysregulation of the immune response to an infection. This may lead to hemodynamic dysfunction and multiple-organ failure. The main aim of this study was to evaluate the effect of coupled plasma filtration adsorption (CPFA) on the hemodynamic profile in patients with septic shock.

Materials and methods: We retrospectively analyzed data from 21 adult patients admitted to the intensive care unit with a diagnosis of septic shock, comparing data between pre-CPFA and post-CPFA treatment. They received a maximum of 5 cycles of treatment.

Results: Coupled plasma filtration adsorption treatment was associated with a significant increase of mean arterial pressure (P < .001), reduction of the vasoactive/inotropic requirement (P = .007), and renal improvement. In patients with leukocytosis or leucopenia, the leukocyte count was restored to a reference range of values.

Conclusion: Treatment with CPFA improves hemodynamic parameters in septic shock patients, ameliorating organ failure.

Keywords: CPFA; Cytokines; Hemodynamics; Multiple organ failure; Septic shock.

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