Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Mar;18(3):206-10.
doi: 10.7499/j.issn.1008-8830.2016.03.003.

[Effect of caffeine citrate on early pulmonary function in preterm infants with apnea]

[Article in Chinese]
Mei Yu  1 , Jin-Hua Huang, Rong Zhu, Xu-Zhong Zhang, Wan-Yun Wu, Xiao-Hong Wen
Affiliations
Randomized Controlled Trial

[Effect of caffeine citrate on early pulmonary function in preterm infants with apnea]

[Article in Chinese]
Mei Yu et al. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar.

Abstract
in English, Chinese

Objective: To investigate the effect of caffeine citrate treatment on early pulmonary function in preterm infants with apnea.

Methods: Forty preterm infants with apnea were randomly divided into aminophylline treatment group (20 infants) and caffeine citrate treatment group (20 infants). When the preterm infants experienced apnea after birth, they were given aminophylline or caffeine citrate in addition to assisted ventilation with continuous positive airway pressure (NCPAP). After drug discontinuation, pulmonary function was measured and compared between the two groups.

Results: After treatment, compared with the aminophylline treatment group, the caffeine citrate treatment group had significantly higher tidal volume, minute ventilation volume, ratio of time to peak tidal expiratory flow to total expiratory time, ratio of volume to peak tidal expiratory flow to total expiratory volume, peak expiratory flow, and breathing flow at 75%, 50%, and 25% of tidal volume (P<0.05). The caffeine citrate treatment group had a significantly shorter time of oxygen use and NCPAP support than the aminophylline treatment group (P<0.01). Compared with the aminophylline treatment group, the caffeine citrate treatment group had a significantly lower frequency of apnea attacks (P<0.01).

Conclusions: In the treatment of apnea in preterm infants, caffeine citrate can improve early pulmonary function and reduce the incidence of apnea.

目的: 探讨枸橼酸咖啡因治疗早产儿呼吸暂停(AOP)对患儿早期肺功能的影响。

方法: 40例AOP患儿随机分为氨茶碱治疗组(20例)和咖啡因治疗组(20例)。2组患儿均在生后出现呼吸暂停时在经鼻持续气道正压通气(NCPAP)辅助通气的基础上给予氨茶碱或枸橼酸咖啡因治疗, 停药后行肺功能检测, 比较两组之间肺功能的变化。

结果: 治疗后咖啡因治疗组潮气量、每分通气量、达峰时间比、达峰容积比、潮气呼吸呼气峰流速及75%、50%、25%潮气量时呼吸流速均高于氨茶碱治疗组(P＜0.05);咖啡因治疗组用氧时间、NCPAP使用时间均低于氨茶碱治疗组(P＜0.01)。与氨茶碱治疗组比较, 咖啡因治疗组用药7 d后呼吸暂停发生频率明显减少(P＜0.01)。

结论: 枸橼酸咖啡因治疗AOP可以改善患儿早期肺功能, 减少呼吸暂停的发生。

PubMed Disclaimer

References

    1. Hjalmarson O, Sandberg K. Abnormal lung function in healthy preterm infants. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=d4ff077b6.... Am J Respir Crit Care Med. 2002;165(1):83–87. - PubMed
    1. Mello RR, Silva KS, Costa AM, et al. Longitudinal assessment of the lung mechanics of very low birth weight preterm infants with and without bronchopulmonary dysplasia. Sao Paulo Med J. 2015;133(5):401–407. doi: 10.1590/1516-3180.2014.00101812. - DOI - PMC - PubMed
    1. Francart SJ, Allen MK, Stegall-Zanation J. Apnea of prematurity: caffeine dose optimization. http://d.old.wanfangdata.com.cn/OAPaper/oai_pubmedcentral.nih.gov_3626066 Pediatr Pharmacol Ther. 2013;18(1):45–52. - PMC - PubMed
    1. Butcher-Puech MC, Henderson-Smart DJ, Holley D, et al. Relation between apnoea duration and type and neurological status of preterm infants. Arch Dis Child. 1985;60(10):953–958. doi: 10.1136/adc.60.10.953. - DOI - PMC - PubMed

    1. ClinicalTrials.gov. Caffeine to reduce mechanical ventilation in preterm infants[DB/OL].[February 3, 2014].http://clinicaltrials.gov/show/NCT01751724.

Publication types