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Comment
. 2016 Mar 15;113(11):2812-4.
doi: 10.1073/pnas.1601512113. Epub 2016 Mar 14.

Moving beyond metagenomics to find the next pandemic virus

Vincent Racaniello  1
Affiliations
Comment

Moving beyond metagenomics to find the next pandemic virus

Vincent Racaniello. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Experimental platform for moving beyond metagenomics to identify viruses with pandemic potential. Samples from animals are subjected to deep, high-throughput sequencing to identify viral genomes. Sequence data are subjected to phylogenetic analyses to identify evolutionary relationships. Selected viral genomes are synthesized as DNAs and transfected into cells to recover virus. Viruses are evaluated for the ability to replicate in relevant human cell culture models and to cause disease in animal models. The latter can also be used to evaluate therapeutics (antivirals and monoclonal antibodies) and vaccines. Images courtesy of (clockwise, Left to Right) Flickr/Michael Pennay, Flickr/Pablo Gonzalez, Andrew Rambaut, Flickr/J. N. Stuart, and the National Cancer Institute.
See this image and copyright information in PMC

Comment on

  • SARS-like WIV1-CoV poised for human emergence.
    Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. Menachery VD, et al. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976607 Free PMC article.

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