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Review
. 2016 Mar;7(2):135-44.
doi: 10.1177/2040622315618393. Epub 2016 Jan 12.

Gout: optimizing treatment to achieve a disease cure

Affiliations
Review

Gout: optimizing treatment to achieve a disease cure

José Antonio Bernal et al. Ther Adv Chronic Dis. 2016 Mar.

Abstract

Gout is one of the most common inflammatory arthritides. The disease is due to the deposition of monosodium urate crystals. These deposits are reversible with proper treatment, suggesting that gout is a curable disease. The main aim in gout is to lower serum uric acid levels to a pre-established target; there are different urate-lowering drugs (xanthine oxidase inhibitors, uricosurics and uricases) through which this can be achieved. Proper treatment of gout also involves correct management of acute flares and their prevention. To ensure treatment adherence it is necessary to explain to the patient what the objectives are.

Keywords: allopurinol; colchicine; gout; monosodium urate crystals; uric acid.

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Conflict of interest statement

Conflict of interest statement: EP has received speaking fees from Menarini. The other authors declare no confilct of interest.

References

    1. Abeles A. (2012) Febuxostat hypersensitivity. J Rheumatol 39: 659. - PubMed
    1. Ahern M., Reid C., Gordon T., McCredie M., Brooks P., Jones M. (1987) Does colchicine work? The results of the first controlled study in acute gout. Aust N Z J Med 17: 301–304. - PubMed
    1. Alloway J., Moriarty M., Hoogland Y., Nashel D. (1993) Comparison of triamcinolone acetonide with indomethacin in the treatment of acute gouty arthritis. J Rheumatol 20: 111–113. - PubMed
    1. Bardin T., Keenan R., Khanna P., Kopicko J., Fung M., Bhakta N., et al. (2015) Lesinurad, a selective uric acid reabsorption inhibitor, in combination with allopurinol: results from a phase III study in gout patients having an inadequate response to standard of care (CLEAR 2). Ann Rheum Dis 74(Suppl. 2): 574.
    1. Bastow M., Durrington P., Ishola M. (1988) Hypertriglyceridemia and hyperuricemia: effects of two fibric acid derivatives (bezafibrate and fenofibrate) in a double-blind, placebo-controlled trial. Metabolism 37: 217–220. - PubMed

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