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. 2016 Mar 2;4(1):e000161.
doi: 10.1136/bmjdrc-2015-000161. eCollection 2016.

Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth

Wen-Peng You  1 , Maciej Henneberg  2
Affiliations

Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth

Wen-Peng You et al. BMJ Open Diabetes Res Care. .

Abstract

Objective: Prevalence of type 1 diabetes (T1D) disease is increasing worldwide. We aim to test correlation of T1D prevalence to the reduced natural selection measured by Biological State Index (Ibs).

Research design and methods: Country-specific estimates of T1D prevalence, life expectancy, obesity prevalence rate, urbanization rates, per capita sugars consumption and per capita gross domestic product (GDP) were obtained. Ibs and country-specific longevity (e50) increase for each country were self-calculated. These data were then matched to T1D prevalence by country for our ecological study among 118 countries. Countries were also grouped to study the associations in different regions. SPSS V.22 was used for correlation analysis.

Results: Worldwide, both Ibs and life expectancy at birth (Ibs proxy) were significantly correlated to T1D prevalence in Pearson r (r=0.713, p<0.001 and r=0.722, p<0.001, respectively) and Spearman's r (r=0.724, p<0.001 and r=0.689, p<0.001, respectively). T1D prevalence was not correlated to longevity increase measured as life expectancy at 50 years old. T1D prevalence was significantly associated with I bs (r=0.307, p<0.001) and newborn life expectancy (r=0.349, p<0.001) independent of per capita total sugar consumption, per capita GDP, urbanization and obesity prevalence in partial correlation. Globally, both life expectancy at birth and Ibs exponentially correlated to T1D prevalence. Pearson correlations generally existed in different country categorizations by geographic region, culture background and economic status.

Conclusions: Reduced natural selection may have contributed to the increasing T1D prevalence worldwide. T1D epidemiology study in total population may be the practical solution to identify the causes of increasing T1D prevalence.

Keywords: Epidemiology; Insulin; Life and Health Expectancy; Type 1.

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Figures

Figure 1
Figure 1
Relationship between Ibs and type 1 diabetes prevalence worldwide.
Figure 2
Figure 2
Relationship between life expectancy (years) at birth and type 1 diabetes prevalence worldwide.
See this image and copyright information in PMC

References

    1. Noble JA, Erlich HA. Genetics of type 1 diabetes. Cold Spring Harb Perspect Med 2012;2:1–15. 10.1101/cshperspect.a007732 - DOI - PMC - PubMed
    1. Steck AK, Rewers MJ. Genetics of type 1 diabetes. Clin Chem 2011;57:176–85. 10.1373/clinchem.2010.148221 - DOI - PMC - PubMed
    1. Frese T, Sandholzer H. The epidemiology of type 1 diabetes mellitus. In: Escher S, Li A, eds. type 1 diabetes. InTech, 2013:1–22.
    1. Maahs DM, West NA, Lawrence JM et al. Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 2010;39:481–97. 10.1016/j.ecl.2010.05.011 - DOI - PMC - PubMed
    1. International Diabetes Federation. Key findings 2014. http://www.idf.org/diabetesatlas/update-2014