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. 2016 Mar 30;138(12):4014-7.
doi: 10.1021/jacs.6b02158. Epub 2016 Mar 18.

Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans

Gustavo M Borrajo-Calleja  1 , Vincent Bizet  1 , Clément Mazet  1
Affiliations

Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans

Gustavo M Borrajo-Calleja et al. J Am Chem Soc. .

Abstract

A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bis-phosphine mono-oxide ligands is crucial, and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

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