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Meta-Analysis
. 2016 Mar 15;11(3):e0150532.
doi: 10.1371/journal.pone.0150532. eCollection 2016.

Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Qingxia Du  1 , Jianmin Jin  1 , Xiaofang Liu  1 , Yongchang Sun  1   2
Affiliations
Meta-Analysis

Bronchiectasis as a Comorbidity of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Qingxia Du et al. PLoS One. .

Abstract

Background: Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Understanding the presence of bronchiectasis in COPD is important for future intervention and preventing disease progression.

Methods: Observational studies were identified from electronic literature searches in Cochrane library, PubMed, ScienceDirect databases, American Thoracic Society and European Respiratory Society meeting abstracts. A systematic review and meta-analysis of studies was performed to summarize the factors associated with bronchiectasis in COPD patients. Primary outcomes included the risks for exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality. Odds ratios (ORs) were pooled by random effects models.

Results: Fourteen observational studies were eligible for the study. Compared with COPD without bronchiectasis, comorbid bronchiectasis in COPD increased the risk of exacerbation (1.97, 95% CI, 1.29-3.00), isolation of a potentially pathogenic microorganism (4.11, 95%CI, 2.16-7.82), severe airway obstruction (1.31, 95% CI, 1.09-1.58) and mortality (1.96, 95% CI, 1.04-3.70).

Conclusions: The presence of bronchiectasis in patients with COPD was associated with exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of process of literature review and selection.
Fig 2
Fig 2. Odd ratios for the association between comorbid bronchiectasis and risk for COPD exacerbations.
Fig 3
Fig 3. Odd ratios for the association between comorbid bronchiectasis and risk for isolation of a potentially pathogenic microorganism.
Fig 4
Fig 4. Odd ratios for the association between comorbid bronchiectasis and risk for severe airway obstruction.
Fig 5
Fig 5. Odd ratios for the association between comorbid bronchiectasis and risk for mortality.
See this image and copyright information in PMC

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