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Review
. 1989 Nov-Dec;140(9):880-3; discussion 918-26.
doi: 10.1016/0923-2494(89)90047-3.

Dendritic cell ontogeny

W E Bowers  1 , E M Goodell
Affiliations
Review

Dendritic cell ontogeny

W E Bowers et al. Res Immunol. 1989 Nov-Dec.

Abstract

Abundant evidence indicates that dendritic cells arise from the bone marrow. In vitro, precursors that differ phenotypically from mature dendritic cells divide several times to form functional dendritic cells. A soluble factor(s) produced in the supernatants of ConA-stimulated spleen cells enhances the production of dendritic cells. This factor(s) has not been fully characterized. Further maturation of dendritic cells occurs after they are released from the bone marrow; species differences exist. Interrelationships between various types of dendritic cells need to be elucidated.

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