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Review
. 2016 Mar;23(2):120-4.
doi: 10.1053/j.ackd.2016.01.017.

Genomics in CKD: Is This the Path Forward?

Girish N Nadkarni  1 , Carol R Horowitz  2
Affiliations
Review

Genomics in CKD: Is This the Path Forward?

Girish N Nadkarni et al. Adv Chronic Kidney Dis. 2016 Mar.

Abstract

Recent advances in genomics and sequencing technology have led to a better understanding of genetic risk in CKD. Genetics could account in part for racial differences in treatment response for medications including antihypertensives and immunosuppressive medications due to its correlation with ancestry. However, there is still a substantial lag between generation of this knowledge and its adoption in routine clinical care. This review summarizes the recent advances in genomics and CKD, discusses potential reasons for its underutilization, and highlights potential avenues for application of genomic information to improve clinical care and outcomes in this particularly vulnerable population.

Keywords: CKD; Disparities; Genetics; Genomics; Pharmacogenomics.

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References

    1. Grams ME, Chow EKH, Segev DL, Coresh J. Lifetime incidence of CKD stages 3–5 in the United States. Am J Kidney Dis Off J Natl Kidney Found. 2013;62(2):245–252. doi: 10.1053/j.ajkd.2013.03.009. - DOI - PMC - PubMed
    1. Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney Disease as a Risk Factor for Development of Cardiovascular Disease A Statement From the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108(17):2154–2169. doi: 10.1161/01.CIR.0000095676.90936.80. - DOI - PubMed
    1. Fried LF, Katz R, Sarnak MJ, et al. Kidney function as a predictor of noncardiovascular mortality. J Am Soc Nephrol JASN. 2005;16(12):3728–3735. doi: 10.1681/ASN.2005040384. - DOI - PubMed
    1. Levey AS, Coresh J. Chronic kidney disease. Lancet. 2012;379(9811):165–180. doi: 10.1016/S0140-6736(11)60178-5. - DOI - PubMed
    1. Nicholas SB, Kalantar-Zadeh K, Norris KC. Racial disparities in kidney disease outcomes. Semin Nephrol. 2013;33(5):409–415. doi: 10.1016/j.semnephrol.2013.07.002. - DOI - PMC - PubMed

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