Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Apr;11(8):891-906.
doi: 10.2217/nnm.16.26. Epub 2016 Mar 16.

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs

Vittoria Di Mauro  1   2 , Michele Iafisco  3 , Nicolò Salvarani  1   2 , Marco Vacchiano  1 , Pierluigi Carullo  1   2 , Gloria Belén Ramírez-Rodríguez  3 , Tatiana Patrício  3 , Anna Tampieri  3 , Michele Miragoli  1   2 , Daniele Catalucci  1   2
Affiliations
Free article

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs

Vittoria Di Mauro et al. Nanomedicine (Lond). 2016 Apr.
Free article

Abstract

Aim: To develop biocompatible and bioresorbable negatively charged calcium phosphate nanoparticles (CaP-NPs) as an innovative therapeutic system for the delivery of bioactive molecules to the heart.

Materials & methods: CaP-NPs were synthesized via a straightforward one-pot biomineralization-inspired protocol employing citrate as a stabilizing agent and regulator of crystal growth. CaP-NPs were administered to cardiac cells in vitro and effects of treatments were assessed. CaP-NPs were administered in vivo and delivery of microRNAs was evaluated.

Results: CaP-NPs efficiently internalized into cardiomyocytes without promoting toxicity or interfering with any functional properties. CaP-NPs successfully encapsulated synthetic microRNAs, which were efficiently delivered into cardiac cells in vitro and in vivo.

Conclusion: CaP-NPs are a safe and efficient drug-delivery system for potential therapeutic treatments of polarized cells such as cardiomyocytes.

Keywords: calcium phosphate nanoparticles; cardiomyocytes; drug-delivery systems; microRNA; nanomedicine.

PubMed Disclaimer

Publication types