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. 2016 Jun;33(6):689-701.
doi: 10.1007/s10815-016-0690-8. Epub 2016 Mar 16.

The effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization: a systematic review

Liying Ying  1   2 , Lai Har Wu  1 , Alice Yuen Loke  3
Affiliations

The effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization: a systematic review

Liying Ying et al. J Assist Reprod Genet. 2016 Jun.

Abstract

Purpose: The purpose of this study was to examine the effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization (IVF), as determined through RCT studies.

Methods: Using the electronic databases PubMed, EMBase, Cochrane Library, CINAHL, PsycInfo, and CAJ, a systematic literature search was conducted in July 2015. MeSH terms, key words, and free words such as "infertility," "fertilization in vitro," "psychotherapy," "intervention," "anxiety," "depression," and "marital satisfaction" were used to identify all potential studies. The quality of the studies that were included was assessed using the risk of bias assessment tool developed by the Cochrane Back Review Group. Descriptive analysis was adopted to synthesize the results.

Results: A total of 20 randomized controlled trials were included in this review. There were reports of positive effects on the anxiety levels, pregnancy rates, or marital function of infertile couples in six studies that adopted different psychosocial approaches, including mind body intervention (Eastern body-mind-spirit, Integrative body-mind-spirit, and Mind/body intervention), cognitive behavioral therapy, group psychotherapy, and harp therapy. However, there were methodological or practical issues related to measurement points and attrition rates in these studies. None of these interventions were found to be efficacious in relieving the depression or stress of individuals or couples undergoing IVF treatment. None of the included studies tackled or measured the mental health status of the couples during the most stressful time of waiting for the pregnancy results of their treatment.

Conclusions: A complex intervention, based on sound evidence, should be developed targeting both females and males of infertile couples undergoing IVF treatment, particularly during the stressful period of waiting for the results of the pregnancy test result and after failed cycles.

Keywords: In vitro fertilization; Infertile couples; Mental health; Pregnancy rate; Psychosocial intervention; Systematic review.

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Figures

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Fig. 1
Literature search and study selection
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References

    1. Ying LY, Wu LH, Loke AY. Gender differences in experiences with and adjustments to infertility: a literature review. Int J Nurs Stud. 2015;52(10):1640–52. doi: 10.1016/j.ijnurstu.2015.05.004. - DOI - PubMed
    1. Pasch LA, Christensen AL. Couples facing fertility problems. In: Schmaling KB, Sher TG, editors. The psychology of couples and illness: theory, research, & practice. Washington DC: American Psychological Association; 2000. pp. 241–67.
    1. Ishihara O, Adamson GD, Dyer S, de Mouzon J, Nygren KG, Sullivan EA, et al. International committee for monitoring assisted reproductive technologies: world report on assisted reproductive technologies, 2007. Fertil Steril. 2015;103(2):402–13. doi: 10.1016/j.fertnstert.2014.11.004. - DOI - PubMed
    1. Verhaak CM, Smeenk JM, Evers AW, Kremer JA, Kraaimaat FW, Braat DD. Women’s emotional adjustment to IVF: a systematic review of 25 years of research. Hum Reprod Update. 2007;13(1):27–36. doi: 10.1093/humupd/dml040. - DOI - PubMed
    1. Wang K, Li J, Zhang JX, Zhang L, Yu J, Jiang P. Psychological characteristics and marital quality of infertile women registered for in vitro fertilization-intracytoplasmic sperm injection in China. Fertil Steril. 2007;87(4):792–8. doi: 10.1016/j.fertnstert.2006.07.1534. - DOI - PubMed

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