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Comment
. 2016 Mar 22;113(12):3127-9.
doi: 10.1073/pnas.1601786113. Epub 2016 Mar 15.

Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome

Emily N C Manoogian  1 , Satchidananda Panda  2
Affiliations
Comment

Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome

Emily N C Manoogian et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Circadian regulation of pyruvate metabolism and fatty acid uptake and oxidation. The circadian clock exerts transcriptional and translational control over many clock-controlled genes (CCG), including the NAMPT gene and other metabolic components. One mechanism in which the molecular clock regulates metabolism is through control of NAD+-dependent protein deacetylases (sirtuins, SIRT). Note, not all forms of circadian regulation of metabolism are depicted. Rate-limiting enzymes are indicated in yellow, metabolites are in gray, catabolic processes in green, and anabolic processes in brown. The hourglass (formula image) signifies protein oscillations that were restored by nighttime feeding in Per1/2−/− mice (11). The circled wave (formula image) indicates oscillating proteins; peak protein accumulation is provided in zeitgeber time (ZT) (11). Protein levels peaking during the day are highlighted in orange, and during the evening in blue. ACC, acetyl-CoA carboxylase; AceCS1, acetyl-CoA synthetase; Hadh, hydroxyacyl-CoA dehydrogenase; LDH, lactate dehydrogenase; MCD, malonyl-CoA decarboxylase; NAMPT, nicotinamide phosphoribosyltransferase; PDH, pyruvate dehydrogenase. All acronyms that are not in bold are genes that code for the enzymes in bold above them.
See this image and copyright information in PMC

Comment on

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