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Review
. 2016 Aug;128(15-16):586-91.
doi: 10.1007/s00508-016-0977-x. Epub 2016 Mar 15.

Association of cytomegalovirus infection with hypertension risk: a meta-analysis

Jing Hui  1 , Yuan-Yuan Qu  1   2 , Na Tang  1 , Yong-Min Liu  1 , Hua Zhong  1 , La-Mei Wang  3 , Qian Feng  1 , Zhen Li  1 , Fang He  4
Affiliations
Review

Association of cytomegalovirus infection with hypertension risk: a meta-analysis

Jing Hui et al. Wien Klin Wochenschr. 2016 Aug.

Abstract

Background: Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.

Methods: We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).

Results: Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95-2.05, P = 0.017). There was significant heterogeneity among the studies included (I(2) = 70.5 %). The funnel plot and Egger's test also indicated no publication bias.

Conclusions: The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.

Keywords: Cytomegalovirus; Essential hypertension; Meta-analysis.

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Conflict of interest statement

Compliance with ethical standards Conflicts of interest J. Hui, Y.-y. Qu, N. Tang, Y.-m. Liu, H. Zhong, L.-m. Wang, Q. Feng, Z. Li, and F. He declare that there are no actual or potential conflicts of interest in relation to this article.

Figures

Fig. 1
Fig. 1
Flow diagram of the study selection process
Fig. 2
Fig. 2
Forest plot of the cytomegalovirus (CMV)-positive rate in hypertension patients versus controls. OR odds ratio, CI confidence interval
Fig. 3
Fig. 3
Sensitivity analysis
Fig. 4
Fig. 4
Funnel plot to evaluate potential publication bias in studies evaluating the association between cytomegalovirus (CMV) and essential hypertension risk
See this image and copyright information in PMC

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