Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Feb;70(1):69-71.
doi: 10.5455/medarh.2016.70.69-71. Epub 2016 Jan 31.

Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature

Anka Aleksic-Shihabi  1 , Eni Jadrijevic  2 , Nina Milekic  1 , Ana Repic Bulicic  2 , Marina Titlic  2 , Enra Suljic  3
Affiliations
Review

Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature

Anka Aleksic-Shihabi et al. Med Arch. 2016 Feb.

Abstract

Introduction: Stroke is a medical emergency in neurology, and is one of the leading causes of death nowadays. At a recent time, a therapeutic method used in adequate conditions is thrombolysis, a treatment of an emerging clot in the brain vascular system by alteplase. The application of alteplase also has a high risk of life threatening conditions.

Case report: This is a brief report of a case with thrombolysis complication which manifested as a spleen rupture.

Keywords: Spleen rupture; Stroke; Thrombolysis.

PubMed Disclaimer

Conflict of interest statement

• Conflict of interest: none declared.

Figures

Figure 1
Figure 1
CT scan of abdomen and pelvis showed a splenic rupture with massive intraperitoneal bleeding in the area of ruptured spleen, perihepatic space, in both paracolic gutters and in the pelvis
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

References

    1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study. The Lancet. 2010;380:2095–128. - PMC - PubMed
    1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue Plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–8. - PubMed
    1. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) JAMA. 1995;274:1017–25. - PubMed
    1. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebocontrolled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European- Australasian Acute Stroke Study Investigators. Lancet. 1998;352:1245–51. - PubMed
    1. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999;282:2019–26. - PubMed

MeSH terms

Substances