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Case Reports
. 2016 Jan-Feb;42(1):68-70.
doi: 10.1590/S1806-37562016000000193.

Angiosarcoma of the lung

[Article in English, Portuguese]
Mónica Grafino  1 , Paula Alves  1 , Margarida Mendes de Almeida  2 , Patrícia Garrido  1 , Direndra Hasmucrai  1 , Encarnação Teixeira  1 , Renato Sotto-Mayor  1
Affiliations
Case Reports

Angiosarcoma of the lung

[Article in English, Portuguese]
Mónica Grafino et al. J Bras Pneumol. 2016 Jan-Feb.

Abstract
in English, Portuguese

Angiosarcoma is a rare malignant vascular tumor. Pulmonary involvement is usually attributable to metastasis from other primary sites, primary pulmonary angiosarcoma therefore being quite uncommon. We report a case of angiosarcoma with pulmonary involvement, probably primary to the lung, which had gone untreated for more than two years. We describe this rare neoplasm and its growth, as well as the extensive local invasion and hematogenous metastasis at presentation. We also discuss its poor prognosis.

O angiosarcoma é um tumor vascular maligno. O envolvimento pulmonar é geralmente atribuído à metástase de outros sítios primários, sendo o angiossarcoma pulmonar primário extremamente raro. Relatamos um caso de angiossarcoma com envolvimento pulmonar, provavelmente primário no pulmão com mais de dois anos de evolução. Descrevemos seu crescimento e sua extensa invasão local e hematogênica na apresentação. Documentamos ainda seu mau prognóstico.

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Figures

Figure 1.
Figure 1.. Evolution of angiosarcoma in a 78-year-old female nonsmoker: in A, initial CT scan of the chest showing a left upper lobe pulmonary mass; in B and C, CT scans of the chest, obtained two years later, showing a 10 × 7 cm lesion in the left upper lobe, with a small left pleural effusion and small mediastinal lymph nodes; in D, an 18F-fluorodeoxyglucose positron emission tomography-CT scan showing increased metabolic activity in many organs, greatest in the mass in the upper left lobe.
Figure 2.
Figure 2.. Photograph of a mass occluding the left upper lobe bronchus.
Figure 3.
Figure 3.. Histological examination of the biopsy specimen: in A, extensive necrosis and hemorrhage; in B, immunohistochemical staining for CD31; in C, immunohistochemical staining for factor VIII-related antigen.
Figura 1.
Figura 1.. Evolução do angiossarcoma em mulher de 78 anos, não tabagista: em A, TC de tórax inicial mostrando massa pulmonar em lobo superior esquerdo; em B e C, TCs de tórax, obtidas dois anos depois, mostrando lesão de 10 × 7 cm em lobo superior esquerdo, com pequeno derrame pleural à esquerda e pequenos linfonodos mediastinais; em D, tomografia por emissão de pósitrons com 18F fluordesoxiglicose combinada à TC mostrando aumento de atividade metabólica em muitos órgãos, maior na massa no lobo superior esquerdo.
Figura 2.
Figura 2.. Fotografia de uma massa ocluindo o brônquio lobar superior esquerdo.
Figura 3.
Figura 3.. Exame histológico da biópsia: em A, extensa necrose e hemorragia; em B, coloração imuno-histoquímica para CD31; em C, coloração imuno-histoquímica para o antígeno relacionado ao fator VIII.
See this image and copyright information in PMC

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